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  Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder

Demirtaş, M., Tornador, C., Falcon, C., Lõpez-Solà, M., Hernández-ribas, R., Pújol, J., et al. (2016). Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder. Human Brain Mapping, 37(8), 2918-2930. doi:10.1002/hbm.23215.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-B4C4-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-6289-2
Genre: Journal Article

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 Creators:
Demirtaş, Murat1, Author
Tornador, Cristian1, Author
Falcon, Carles2, 3, Author
Lõpez-Solà, Marina4, 5, Author
Hernández-ribas, Rosa6, 7, Author
Pújol, Jesús8, Author
Menchón, Jose M.6, 7, 9, Author
Ritter, Petra10, 11, Author           
Cardoner, N.12, 13, Author
Soriano-Mas, Carles6, 7, 14, Author
Deco, Gustavo1, 15, Author           
Affiliations:
1Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2BarcelonaBeta Brain Research Center, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain, ou_persistent22              
4Department of Psychology and Neuroscience, University of Colorado Boulder, CO, USA, ou_persistent22              
5MRI Research Unit, CRC Mar, Hospital del Mar, Barcelona, Spain, ou_persistent22              
6Centro de Investigación en Red de Salud Mental (CIBERSAM), Sant Boi de Llobregat, Spain, ou_persistent22              
7Psychiatry Department, Bellvitge Biomedical Research Institute (IDIBELL), Llobregat, Spain, ou_persistent22              
8Department of Radiology, MRI Research Unit, Hospital del Mar, Barcelona, Spain, ou_persistent22              
9Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Spain, ou_persistent22              
10Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
11Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
12Mental Health Department, Depression and Anxiety Program, Parc Taulí Sabadell, Barcelona, Spain, ou_persistent22              
13Department of Psychiatry and Legal Medicine, Universitat Autònoma De Barcelona, Spain, ou_persistent22              
14Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma De Barcelona, Spain, ou_persistent22              
15Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, ou_persistent22              

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Free keywords: Dynamic functional connectivity; fMRI; Major depressive disorder; Mood disorders; Resting state
 Abstract: Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network.

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Language(s): eng - English
 Dates: 2016-03-142015-07-082016-04-052016-04-282016-08
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.23215
PMID: 27120982
PMC: PMC5074271
Other: Epub 2016
 Degree: -

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Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : PSI2013-42091-P
Funding program : Research Personnel Training program
Funding organization : Spanish Ministry of Economy and Competitiveness
Project name : The Human Brain Project / HBP
Grant ID : 604102
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : CP10/00604
Funding program : -
Funding organization : del Carlos III Health Institute

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 37 (8) Sequence Number: - Start / End Page: 2918 - 2930 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686