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  A low-molecular-weight ditopic MRI probe for ratiometric sensing of zwitterionic amino acid neurotransmitters

Toljić, Đ., & Angelovski, G. (2019). A low-molecular-weight ditopic MRI probe for ratiometric sensing of zwitterionic amino acid neurotransmitters. Chemical Communications, 55(79), 11924-11927. doi:10.1039/c9cc06463j.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-B6BB-C Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C90F-A
Genre: Journal Article

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Toljić, Đ1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              

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 Abstract: We report a novel ditopic Gd(III)-based probe selective to zwitterionic amino acid neurotransmitters (ZNTs) crafted for ratiometric MRI imaging. The probe displayed increased binding affinity to ZNTs and non-synchronized concentration-dependent changes of the r1- and r2-relaxivity. Through the application of a T2/T1 weighted MRI strategy, we demonstrated signal enhancement for cooperatively bound glutamate and γ-aminobutyric acid ZNTs over competitive hydrogencarbonate, which remained MR silent.

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 Dates: 2019-092019-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/c9cc06463j
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 55 (79) Sequence Number: - Start / End Page: 11924 - 11927 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413