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  Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications

Kemkemer, R., Zenghao, Z., Linxiao, Y., Athanasopulu, K., Frey, K., Cui, Z., et al. (2019). Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications. Current Directions in Biomedical Engineering, 5(1), 93-96. doi:10.1515/cdbme-2019-0024.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-BFE8-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-BFE9-F
Genre: Journal Article

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CurrDirektBiomedEngin_5_2019_93.pdf (Any fulltext), 638KB
 
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 Creators:
Kemkemer, Ralf1, Author              
Zenghao, Zhang, Author
Linxiao, Yang, Author
Athanasopulu, Kiriaki, Author
Frey, Kerstin, Author
Cui, Zhishan, Author
Su, Haijia, Author
Luo, Liu, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: PDMS; alginate; hydrogel; microfluidic chips; cell culture
 Abstract: In vitro, hydrogel-based ECMs for functionalizing surfaces of various material have played an essential role in mimicking native tissue matrix. Polydimethylsiloxane (PDMS) is widely used to build microfluidic or organ-on-chip devices compatible with cells due to its easy handling in cast replication. Despite such advantages, the limitation of PDMS is its hydrophobic surface property. To improve wettability of PDMS-based devices, alginate, a naturally derived polysaccharide, was covalently bound to the PDMS surface. This alginate then crosslinked further hydrogel onto the PDMS surface in desired layer thickness. Hydrogel-modified PDMS was used for coating a topography chip system and in vitro investigation of cell growth on the surfaces. Moreover, such hydrophilic hydrogel-coated PDMS is utilized in a microfluidic device to prevent unspecific absorption of organic solutions. Hence, in both exemplary studies, PDMS surface properties were modified leading to improved devices.

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Language(s): eng - English
 Dates: 2019-09-182019-09-01
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1515/cdbme-2019-0024
 Degree: -

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Title: Current Directions in Biomedical Engineering
Source Genre: Journal
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Publ. Info: Berlin : De Gruyter
Pages: - Volume / Issue: 5 (1) Sequence Number: - Start / End Page: 93 - 96 Identifier: ISSN: 2364-5504
CoNE: https://pure.mpg.de/cone/journals/resource/2364-5504