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  Cortical laminar resting‐state signal fluctuations scale with the hypercapnic blood oxygenation level‐dependent response

Guidi, M., Huber, L., Lampe, L., Merola, A., Ihle, K., & Möller, H. E. (2020). Cortical laminar resting‐state signal fluctuations scale with the hypercapnic blood oxygenation level‐dependent response. Human Brain Mapping. doi:10.1002/hbm.24926.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-F721-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-AA3C-9
Genre: Journal Article

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 Creators:
Guidi, Maria1, Author              
Huber, Laurentius1, Author              
Lampe, Leonie1, Author              
Merola, Alberto2, Author              
Ihle, Kristin1, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: 7 T‐fMRI; calibrated fMRI; hypercapnia; laminar fMRI; resting‐state fMRI; VASO
 Abstract: Calibrated functional magnetic resonance imaging can remove unwanted sources of signal variability in the blood oxygenation level‐dependent (BOLD) response. This is achieved by scaling, using information from a perfusion‐sensitive scan during a purely vascular challenge, typically induced by a gas manipulation or a breath‐hold task. In this work, we seek for a validation of the use of the resting‐state fluctuation amplitude (RSFA) as a scaling factor to remove vascular contributions from the BOLD response. Given the peculiarity of depth‐dependent vascularization in gray matter, BOLD and vascular space occupancy (VASO) data were acquired at submillimeter resolution and averaged across cortical laminae. RSFA from the primary motor cortex was, thus, compared to the amplitude of hypercapnia‐induced signal changes (tSDhc) and with the M factor of the Davis model on a laminar level. High linear correlations were observed for RSFA and tSDhc ( R2 = 0.92 ± 0.06) and somewhat reduced for RSFA and M ( R2 = 0.62 ± 0.19). Laminar profiles of RSFA‐normalized BOLD signal changes yielded good agreement with corresponding VASO profiles. Overall, this suggests that RSFA contains strong vascular components and is also modulated by baseline quantities contained in the M factor. We conclude that RSFA may replace the scaling factor tSDhc for normalizing the laminar BOLD response.

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Language(s): eng - English
 Dates: 2019-12-192019-10-022020-01-052020-01-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.24926
PMID: 31957959
Other: Epub ahead of print
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Project name : Ultra-High Field Magnetic Resonance Imaging / HIMR
Grant ID : 316716
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : 016.Veni.198.032
Funding program : Veni grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686