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  Higher body mass index is linked to altered hypothalamic microstructure

Thomas, K., Beyer, F., Lewe, G., Zhang, R., Schindler, S., Schönknecht, P., et al. (2019). Higher body mass index is linked to altered hypothalamic microstructure. Scientific Reports, 9: 17373. doi:10.1038/s41598-019-53578-4.

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 Urheber:
Thomas, Kevin1, 2, Autor           
Beyer, Frauke1, 2, Autor           
Lewe, Gesa1, Autor
Zhang, Rui1, Autor           
Schindler, Stephanie3, 4, Autor           
Schönknecht, P.3, Autor
Stumvoll, M.5, Autor
Villringer, Arno1, 2, 6, 7, Autor           
Witte, A. Veronica1, 2, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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 Zusammenfassung: Animal studies suggest that obesity-related diets induce structural changes in the hypothalamus, a key brain area involved in energy homeostasis. Whether this translates to humans is however largely unknown. Using a novel multimodal approach with manual segmentation, we here show that a higher body mass index (BMI) selectively predicted higher proton diffusivity within the hypothalamus, indicative of compromised microstructure in the underlying tissue, in a well-characterized population-based cohort (n1 = 338, 48% females, age 21–78 years, BMI 18–43 kg/m²). Results were independent from confounders and confirmed in another independent sample (n2 = 236). In addition, while hypothalamic volume was not associated with obesity, we identified a sexual dimorphism and larger hypothalamic volumes in the left compared to the right hemisphere. Using two large samples of the general population, we showed that a higher BMI specifically relates to altered microstructure in the hypothalamus, independent from confounders such as age, sex and obesity-associated co-morbidities. This points to persisting microstructural changes in a key regulatory area of energy homeostasis occurring with excessive weight. Our findings may help to better understand the pathomechanisms of obesity and other eating-related disorders.

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Sprache(n): eng - English
 Datum: 2019-07-312019-11-012019-11-22
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41598-019-53578-4
PMID: 31758009
 Art des Abschluß: -

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Projektname : Obesity Mechanisms / SFB 1052
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Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
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Grant ID : WI 3342/3-1
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Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
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Förderorganisation : European Commission (EC) (EC)
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Förderprogramm : European Regional Development Fund
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Free State of Saxony
Projektname : -
Grant ID : 713-241202, 14505/2470 ; 14575/2470 ; 100329290
Förderprogramm : -
Förderorganisation : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig

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Titel: Scientific Reports
  Kurztitel : Sci. Rep.
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: London, UK : Nature Publishing Group
Seiten: - Band / Heft: 9 Artikelnummer: 17373 Start- / Endseite: - Identifikator: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322