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  Higher body mass index is linked to altered hypothalamic microstructure

Thomas, K., Beyer, F., Lewe, G., Zhang, R., Schindler, S., Schönknecht, P., et al. (2019). Higher body mass index is linked to altered hypothalamic microstructure. Scientific Reports, 9: 17373. doi:10.1038/s41598-019-53578-4.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0005-4CC5-8 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-589D-8
Genre: Journal Article

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 Creators:
Thomas, Kevin1, 2, Author           
Beyer, Frauke1, 2, Author           
Lewe, Gesa1, Author
Zhang, Rui1, Author           
Schindler, Stephanie3, 4, Author           
Schönknecht, P.3, Author
Stumvoll, M.5, Author
Villringer, Arno1, 2, 6, 7, Author           
Witte, A. Veronica1, 2, Author           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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 Abstract: Animal studies suggest that obesity-related diets induce structural changes in the hypothalamus, a key brain area involved in energy homeostasis. Whether this translates to humans is however largely unknown. Using a novel multimodal approach with manual segmentation, we here show that a higher body mass index (BMI) selectively predicted higher proton diffusivity within the hypothalamus, indicative of compromised microstructure in the underlying tissue, in a well-characterized population-based cohort (n1 = 338, 48% females, age 21–78 years, BMI 18–43 kg/m²). Results were independent from confounders and confirmed in another independent sample (n2 = 236). In addition, while hypothalamic volume was not associated with obesity, we identified a sexual dimorphism and larger hypothalamic volumes in the left compared to the right hemisphere. Using two large samples of the general population, we showed that a higher BMI specifically relates to altered microstructure in the hypothalamus, independent from confounders such as age, sex and obesity-associated co-morbidities. This points to persisting microstructural changes in a key regulatory area of energy homeostasis occurring with excessive weight. Our findings may help to better understand the pathomechanisms of obesity and other eating-related disorders.

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Language(s): eng - English
 Dates: 2019-07-312019-11-012019-11-22
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-019-53578-4
PMID: 31758009
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Project name : Obesity Mechanisms / SFB 1052
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)
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Grant ID : WI 3342/3-1
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)
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Funding organization : European Commission (EC) (EC)
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
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Funding organization : Free State of Saxony
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Grant ID : 713-241202, 14505/2470 ; 14575/2470 ; 100329290
Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 17373 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322