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  Automated glycan assembly of arabinomannan oligosaccharides from Mycobacterium tuberculosis

Pardo-Vargas, A., Bharate, P., Delbianco, M., & Seeberger, P. H. (2019). Automated glycan assembly of arabinomannan oligosaccharides from Mycobacterium tuberculosis. Beilstein Journal of Organic Chemistry, 15, 2936-2940. doi:10.3762/bjoc.15.288.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-5981-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-611E-C
Genre: Journal Article

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 Creators:
Pardo-Vargas, Alonso1, Author              
Bharate, Priya2, Author              
Delbianco, Martina3, Author              
Seeberger, Peter H.1, Author              
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
2Peter H. Seeberger - Nanoparticles and Colloidal Polymers, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863307              
3Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2559692              

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Free keywords: arabinomannan; automated glycan assembly; capping
 Abstract: Arabinomannan (AM) polysaccharides are clinical biomarkers for Mycobacterium tuberculosis (MTB) infections due to their roles in the interaction with host cells and interference with macrophage activation. Collections of defined AM oligosaccharides can help to improve the understanding of these polysaccharides and the development of novel therapeutical and diagnostic agents. Automated glycan assembly (AGA) was employed to prepare the core structure of AM from MTB, containing α-(1,6)-Man, α-(1,5)-Ara, and α-(1,2)-Man linkages. The introduction of a capping step after each glycosylation and further optimized reaction conditions allowed for the synthesis of a series of oligosaccharides, ranging from hexa- to branched dodecasaccharides.

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Language(s): eng - English
 Dates: 2019-12-062019
 Publication Status: Published in print
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 Identifiers: DOI: 10.3762/bjoc.15.288
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Title: Beilstein Journal of Organic Chemistry
Source Genre: Journal
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Publ. Info: Frankfurt, Germany : Beilstein-Institut
Pages: - Volume / Issue: 15 Sequence Number: - Start / End Page: 2936 - 2940 Identifier: ISSN: 1860-5397