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  Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish

Shah, G., Thierbach, K., Schmid, B., Waschke, J., Reade, A., Hlawitschka, M., Roeder, I., Scherf, N., & Huisken, J. (2019). Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish. Nature Communications, 10:. doi:10.1038/s41467-019-13625-0.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0005-638F-B 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0005-7AD4-3
資料種別: 学術論文

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Shah_2019.pdf (出版社版), 6MB
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https://hdl.handle.net/21.11116/0000-0005-6391-7
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Shah_2019.pdf
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作成者

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 作成者:
Shah, Gopi1, 2, 著者
Thierbach, Konstantin3, 4, 著者           
Schmid, Benjamin1, 5, 著者
Waschke, Johannes6, 7, 著者           
Reade, Anna8, 9, 著者
Hlawitschka, Mario7, 著者
Roeder, Ingo3, 著者
Scherf, Nico4, 著者           
Huisken, Jan1, 10, 著者
所属:
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, ou_persistent22              
2European Molecular Biology Laboratory (EMBL), Barcelona, Spain, ou_persistent22              
3Institute for Medical Informatics and Biometry, University Hospital Carl Gustav Carus, Dresden, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Optical Imaging Centre Erlangen (OICE), Friedrich Alexander University Erlangen, Germany, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Faculty of Computer Science and Media, University of Applied Sciences, Germany, ou_persistent22              
8Cardiovascular Research Institute (CVRI), University of California, San Francisco, CA, USA, ou_persistent22              
9Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA, ou_persistent22              
10Morgridge Institute for Research, Madison, WI, USA, ou_persistent22              

内容説明

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キーワード: Gastrulation; Light-sheet microscopy
 要旨: The coordination of cell movements across spatio-temporal scales ensures precise positioning of organs during vertebrate gastrulation. Mechanisms governing such morphogenetic movements have been studied only within a local region, a single germlayer or in whole embryos without cell identity. Scale-bridging imaging and automated analysis of cell dynamics are needed for a deeper understanding of tissue formation during gastrulation. Here, we report pan-embryo analyses of formation and dynamics of all three germlayers simultaneously within a developing zebrafish embryo. We show that a distinct distribution of cells in each germlayer is established during early gastrulation via cell movement characteristics that are predominantly determined by their position in the embryo. The differences in initial germlayer distributions are subsequently amplified by a global movement, which organizes the organ precursors along the embryonic body axis, giving rise to the blueprint of organ formation. The tools and data are available as a resource for the community.

資料詳細

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言語: eng - English
 日付: 2018-11-062019-11-172019-12-17
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41467-019-13625-0
PMID: 31848345
PMC: PMC6917746
 学位: -

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Project information

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Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : Smart Multimodal Microscopy for High-Throughput Developmental Biology in Real-Time / SmartMic
Grant ID : 647885
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Morgridge Institute for Research
Project name : -
Grant ID : -
Funding program : -
Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Project name : -
Grant ID : -
Funding program : Institutional Strategy, measure “support the best”
Funding organization : German Federal and State Governments

出版物 1

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出版物名: Nature Communications
  省略形 : Nat. Commun.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London : Nature Publishing Group
ページ: - 巻号: 10 通巻号: 5753 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723