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  A novel approach to localize cortical TMS effects

Weise, K., Numssen, O., Thielscher, A., Hartwigsen, G., & Knösche, T. R. (2020). A novel approach to localize cortical TMS effects. NeuroImage, 209: 116486. doi:10.1016/j.neuroimage.2019.116486.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-651B-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-9C26-1
Genre: Journal Article

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 Creators:
Weise, Konstantin1, 2, Author              
Numssen, Ole3, Author              
Thielscher, Axel4, 5, Author
Hartwigsen, Gesa3, Author              
Knösche, Thomas R.1, 6, Author              
Affiliations:
1Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205650              
2Department of Advanced Electromagnetics, TU Ilmenau, Germany, ou_persistent22              
3Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
4Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark, ou_persistent22              
5Department of Health Technology, Technical University of Denmark, Lyngby, Denmark, ou_persistent22              
6Institute for Biomedical Engineering and Informatics, TU Ilmenau, Germany, ou_persistent22              

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Free keywords: Brain mapping; Finite element analysis; Motor cortex; Transcranial magnetic stimulation; Uncertainty and sensitivity analysis; Motor threshold
 Abstract: Despite the widespread use of transcranial magnetic stimulation (TMS), the precise cortical locations underlying the resulting physiological and behavioral effects are still only coarsely known. To date, mapping strategies have relied on projection approaches (often termed “center of gravity” approaches) or maximum electric field value evaluation, and therefore localize the stimulated cortical site only approximately and indirectly. Focusing on the motor cortex, we present and validate a novel method to reliably determine the effectively stimulated cortical site at the individual subject level. The approach combines measurements of motor evoked potentials (MEPs) at different coil positions and orientations with numerical modeling of induced electric fields. We identify sharply bounded cortical areas, around the gyral crowns and rims of the motor hand area, as the origin of MEPs and show that the magnitude of the tangential component and the overall magnitude of the electric field are most relevant for the observed effect. To validate our approach, we identified the coil location and orientation that produces the maximal electric field at the predicted stimulation site, and then experimentally show that this location produces MEPs more efficiently than other tested locations/orientations. Moreover, we used extensive uncertainty and sensitivity analyses to verify the robustness of the method and identify the most critical model parameters. Our generic approach improves the localization of the cortical area effectively stimulated by TMS and may be transferred to other modalities such as language mapping.

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Language(s): eng - English
 Dates: 2019-12-122019-03-272019-12-192019-12-232020-04-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.116486
Other: Epub ahead of print
PMID: 31877374
 Degree: -

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Project name : -
Grant ID : WE 59851/1
Funding program : -
Funding organization : German Science Foundation (DFG)
Project name : -
Grant ID : R118-A11308
Funding program : -
Funding organization : Lundbeckfonden
Project name : -
Grant ID : -
Funding program : -
Funding organization : NVIDIA Corporation
Project name : -
Grant ID : NNF14OC0011413
Funding program : -
Funding organization : NovoNordisk fonden

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 209 Sequence Number: 116486 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166