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  Site‐Selective Late‐Stage Aromatic [18F]Fluorination via Aryl Sulfonium Salts

Xu, P., Zhao, D., Berger, F., Hamad, A., Rickmeier, J., Petzold, R., et al. (2020). Site‐Selective Late‐Stage Aromatic [18F]Fluorination via Aryl Sulfonium Salts. Angewandte Chemie, International Edition, 59(5), 1956-1960. doi:10.1002/anie.201912567.

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Genre: Journal Article

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 Creators:
Xu, Peng1, Author              
Zhao, Da1, Author              
Berger, Florian1, Author              
Hamad, Aboubakr1, Author              
Rickmeier, Jens1, Author              
Petzold, Roland1, Author              
Kondratiuk, Mykhailo1, Author              
Bohdan, Kostiantyn1, Author              
Ritter, Tobias1, Author              
Affiliations:
1Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              

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Free keywords: 18F labeling; C-H functionalization; fluorination; late-stage functionalization; radiochemistry
 Abstract: Site‐selective functionalization of C−H bonds in small complex molecules is a long‐standing challenge in organic chemistry. Herein, we report a broadly applicable and site‐selective aromatic C−H dibenzothiophenylation reaction. The conceptual advantage of this transformation is further demonstrated through the two‐step C−H [18F]fluorination of a series of marketed small‐molecule drugs.

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Language(s): eng - English
 Dates: 2019-10-012019-11-072020-01-27
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201912567
 Degree: -

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Title: Angewandte Chemie, International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 59 (5) Sequence Number: - Start / End Page: 1956 - 1960 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851