ausblenden:
Schlagwörter:
18F labeling; C-H functionalization; fluorination; late-stage functionalization; radiochemistry
Zusammenfassung:
Site‐selective functionalization of C−H bonds in small complex molecules is a long‐standing challenge in organic chemistry. Herein, we report a broadly applicable and site‐selective aromatic C−H dibenzothiophenylation reaction. The conceptual advantage of this transformation is further demonstrated through the two‐step C−H [18F]fluorination of a series of marketed small‐molecule drugs.
