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  Emergence of human-adapted Salmonella enterica is linked to the Neolithization process

Key, F. M., Posth, C., Esquivel Gomez, L. R., Hübler, R., Spyrou, M. A., Neumann, G. U., et al. (2020). Emergence of human-adapted Salmonella enterica is linked to the Neolithization process. Nature Ecology & Evolution, 4(3), 324-333. doi:10.1038/s41559-020-1106-9.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-BEBA-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-BEBF-F
Genre: Journal Article

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Key, Felix M.1, Author              
Posth, Cosimo1, Author              
Esquivel Gomez, Luis Roger2, Author              
Hübler, Ron1, Author              
Spyrou, Maria A.1, Author              
Neumann, Gunnar U.1, Author              
Furtwängler, Anja, Author
Sabin, Susanna1, Author              
Burri Promerová, Marta1, Author              
Wissgott, Antje1, Author              
Lankapalli, Aditya Kumar1, Author              
Vågene, Åshild J.1, Author              
Meyer, Matthias, Author
Nagel, Sarah, Author
Tukhbatova, Rezeda1, Author              
Khokhlov, Aleksandr, Author
Chizhevsky, Andrey, Author
Hansen, Svend, Author
Belinsky, Andrey B., Author
Kalmykov, Alexey, Author
Kantorovich, Anatoly R., AuthorMaslov, Vladimir E., AuthorStockhammer, Philipp W.3, Author              Vai, Stefania, AuthorZavattaro, Monica, AuthorRiga, Alessandro, AuthorCaramelli, David, AuthorSkeates, Robin, AuthorBeckett, Jessica, AuthorGradoli, Maria Giuseppina, AuthorSteuri, Noah, AuthorHafner, Albert, AuthorRamstein, Marianne, AuthorSiebke, Inga, AuthorLösch, Sandra, AuthorErdal, Yilmaz Selim, AuthorAlikhan, Nabil-Fareed, AuthorZhou, Zhemin, AuthorAchtman, Mark, AuthorBos, Kirsten4, Author              Reinhold, Sabine, AuthorHaak, Wolfgang1, Author              Kühnert, Denise2, Author              Herbig, Alexander1, Author              Krause, Johannes3, Author               more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2tide, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591691              
3MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              
4CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society, ou_3033585              

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 Abstract: It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight Salmonella enterica subsp. enterica genomes from human skeletons of transitional foragers, pastoralists and agropastoralists in western Eurasia that were up to 6,500 yr old. Despite the high genetic diversity of S. enterica, all ancient bacterial genomes clustered in a single previously uncharacterized branch that contains S. enterica adapted to multiple mammalian species. All ancient bacterial genomes from prehistoric (agro-)pastoralists fall within a part of this branch that also includes the human-specific S. enterica Paratyphi C, illustrating the evolution of a human pathogen over a period of 5,000 yr. Bacterial genomic comparisons suggest that the earlier ancient strains were not host specific, differed in pathogenic potential and experienced convergent pseudogenization that accompanied their downstream host adaptation. These observations support the concept that the emergence of human-adapted S. enterica is linked to human cultural transformations.

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Language(s): eng - English
 Dates: 2020-02-242020-03
 Publication Status: Published in print
 Pages: 22
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41559-020-1106-9
Other: shh2524
 Degree: -

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Project name : PALEoRIDER
Grant ID : 771234
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: Nature Ecology & Evolution
  Other : Nature Ecology and Evolution
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 4 (3) Sequence Number: - Start / End Page: 324 - 333 Identifier: ISSN: 2397-334X
CoNE: https://pure.mpg.de/cone/journals/resource/2397-334X