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  Fuse or die: Shaping mitochrondrial fate during starvation

Rambold, A., Kostelecky, B., & Lippencott-Schwarz, J. (2011). Fuse or die: Shaping mitochrondrial fate during starvation. Communicative & Integrative Biology, 4, 752-754. doi:10.4161/cib.17667.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0005-C438-F Version Permalink: https://hdl.handle.net/21.11116/0000-0005-C439-E
Genre: Journal Article

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Rambold et al..pdf (Publisher version), 250KB
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306350/ (Publisher version)
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 Creators:
Rambold, Angelika1, Author           
Kostelecky , B.2, Author
Lippencott-Schwarz, J.2, Author
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1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243650              
2External Organizations, ou_persistent22              

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 Abstract: Mitochondria continuously change their shape and thereby influence different cellular processes like cell death or development. Recently, we showed that during starvation mitochondria fuse into a highly connected network. The change in mitochondrial shape was dependent on inactivation of the fission protein Drp1, through targeting of two different phosphorylation sites. This rapid inhibition of mitochondrial fission led to unopposed fusion, protecting mitochondria from starvation-induced degradation and enabling the cell to survive nutrient scarce conditions.

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Language(s): eng - English
 Dates: 2011
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.4161/cib.17667
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Title: Communicative & Integrative Biology
Source Genre: Journal
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Publ. Info: Austin, Tex. : Landes Bioscience
Pages: - Volume / Issue: 4 Sequence Number: - Start / End Page: 752 - 754 Identifier: ISSN: 1942-0889
CoNE: https://pure.mpg.de/cone/journals/resource/1942-0889