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  Total synthesis of polysaccharides by automated glycan assembly

Joseph, A. A. S., Pardo-Vargas, A., & Seeberger, P. H. (2020). Total synthesis of polysaccharides by automated glycan assembly. Journal of the American Chemical Society, 142(19), 8561-8564. doi:10.1021/jacs.0c00751.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-6C7D-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-6C80-0
Genre: Journal Article

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Joseph, Abragam A. S.1, Author              
Pardo-Vargas, Alonso1, Author              
Seeberger, Peter H.1, Author              
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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 Abstract: Polysaccharides are the most abundant biopolymers on earth that serve various structural and modulatory functions. Pure, completely defined linear and branched polysaccharides are essential to understand carbohydrate structure and function. Polysaccharide isolation provides heterogeneous mixtures, while heroic efforts were required to complete chemical and/or enzymatic syntheses of polysaccharides as long 92-mers. Here, we show that automated glycan assembly (AGA) enables access to a 100-mer polysaccharide via a 201-step synthesis within 188 h. Convergent block coupling of 30- and 31-mer oligosaccharide fragments, prepared by AGA, yielded a multiple-branched 151-mer polymannoside. Quick access to polysaccharides provides the basis for future material science applications of carbohydrates.

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Language(s): eng - English
 Dates: 2020-04-272020
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/jacs.0c00751
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Title: Journal of the American Chemical Society
  Other : JACS
  Abbreviation : J. Am. Chem. Soc.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 142 (19) Sequence Number: - Start / End Page: 8561 - 8564 Identifier: ISSN: 0002-7863