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  Deciphering the contribution of extracellular glutamate and intracellular calcium signaling to the BOLD fMRI signal

Jiang, Y., Chen, X., Pais Roldán, P., Rosen, B., & Yu, X. (2020). Deciphering the contribution of extracellular glutamate and intracellular calcium signaling to the BOLD fMRI signal. In 2020 ISMRM & SMRT Virtual Conference & Exhibition (pp. 492).

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Item Permalink: https://hdl.handle.net/21.11116/0000-0006-D7BF-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0006-E7D3-7
Genre: Meeting Abstract

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https://www.ismrm.org/20/program_files/O75.htm (Abstract)
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 Creators:
Jiang, Y, Author           
Chen, X1, 2, Author           
Pais Roldán, P1, 2, Author           
Rosen, B, Author
Yu, X1, 2, Author           
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: We established a multi-modal fMRI platform with two-channel fiber optic recording based on a genetically encoded fluorescent reporter, iGluSnFR, for extracellular glutamate (Glu) sensing and intracellular calcium indicator, GCaMP6f. Different from the intracellular neuronal and astrocytic calcium transients, the Glu signal, peak responses of spikes and baseline drift, show unique correlation features to the BOLD fMRI signal. Here, we applied the multi-modal fMRI platform to decipher the cellular and molecular interaction underlying the BOLD fMRI signal through the neuro-glio-vascular network in animal brains.

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 Dates: 2020-08
 Publication Status: Published online
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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
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Start-/End Date: 2020-08-08 - 2020-08-14

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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1340 Start / End Page: 492 Identifier: -