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  The cellular heat shock response monitored by chemical exchange saturation transfer MRI

Kleimaier, D., Goerke, S., Nies, C., Zaiss, M., Kunz, P., Gottwald, E., et al. (2020). The cellular heat shock response monitored by chemical exchange saturation transfer MRI. Poster presented at 2020 ISMRM & SMRT Virtual Conference & Exhibition.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-D8B8-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-D8B9-6
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Kleimaier, D, Author
Goerke, S, Author
Nies, C, Author
Zaiss, M1, Author              
Kunz, P, Author
Gottwald, E, Author
Schad, LR, Author
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1External Organizations, ou_persistent22              

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 Abstract: Chemical exchange saturation transfer of the relayed nuclear Overhauser effect(rNOE) enables detection of mobile protein protons via their exchange with the water signal. Recent studies have shown a close relationship between the rNOE-signal and the protein conformation. This study used the -3.5ppm rNOE-signal to monitor the heat shock response of HepG2 cells in a microcavity array-based bioreactor system. A significant drop of the rNOE-signal to 92.4±1.3% and a slow, steady increase of the rNOE-signal for 136.1±13.6min after heat shock were observed. Therefore, the rNOE-signal in CEST spectroscopic imaging is a sensitive readout for the cellular heat shock response.

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 Dates: 2020-08
 Publication Status: Published online
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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
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Start-/End Date: 2020-08-08 - 2020-08-14

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Title: 2020 ISMRM & SMRT Virtual Conference & Exhibition
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 3131 Start / End Page: - Identifier: -