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  The hippocampus maps concept space, not feature space

Theves, S., Fernández, G., & Doeller, C. F. (2020). The hippocampus maps concept space, not feature space. The Journal of Neuroscience, 40(38), 7318-7325. doi:10.1523/JNEUROSCI.0494-20.2020.

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 Urheber:
Theves, Stephanie1, 2, Autor           
Fernández, Guillén2, Autor
Doeller, Christian F.1, 3, Autor           
Affiliations:
1Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              

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 Zusammenfassung: The hippocampal formation encodes maps of space and a key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of non-spatial, conceptual information. Previous work demonstrated directional coding during navigation through a continuous stimulus feature space as well as mapping of distances in a feature space that was relevant for concept learning. Here we provide the first unambiguous evidence for a hippocampal representation of the actual concept space, by showing that the hippocampal distance signal selectively reflects the mapping of specifically conceptually relevant rather than of all feature dimensions. During fMRI scanning of 32 human participants (21 females), we presented every-day objects, which had beforehand been associated with specific values on three continuous feature dimensions. Crucially, only two dimensions were relevant to prior concept learning. We find that hippocampal responses to the objects reflect their relative distances in a space defined along conceptually relevant dimensions as compared to distances in a space defined along all feature dimensions. These findings suggest that the hippocampus supports knowledge acquisition by dynamically encoding information in a space spanned along dimensions that are relevant in relation to define concepts.Statement of significanceHow are neural representations of conceptual knowledge organized, such that humans are able to infer never experienced relations or categorize new exemplars? Map-like representations as supported by the hippocampal formation to encode physical space during navigation have been suggested as a suitable format. Here we provide the first evidence for a hippocampal representation of a conceptual space as compared to a general feature-based space.

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Sprache(n): eng - English
 Datum: 2020-07-142020-03-012020-07-152020-08-212020-09-16
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
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 Identifikatoren: DOI: 10.1523/JNEUROSCI.0494-20.2020
Anderer: epub 2020
PMID: 32826311
 Art des Abschluß: -

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Grant ID : NWO-Gravitation 024-001-006; NWO-Vidi 452-12-009; NWO-MaGW 406-14-114; NWO-MaGW 406-15-291
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Förderorganisation : Netherlands Organization for Scientific Research (NWO)
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Förderorganisation : Max Planck Society
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Förderorganisation : Kavli Foundation
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Grant ID : ERC-CoG GEOCOG 724836
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Förderorganisation : European Research Council (ERC)
Projektname : Centre for Neural Computation
Grant ID : 223262/F50
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Förderorganisation : Research Council of Norway
Projektname : NORBRAIN
Grant ID : 197467/F50
Förderprogramm : -
Förderorganisation : Research Council of Norway
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Förderorganisation : Max Planck Society
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Förderorganisation : Foundation CELLEX
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Förderorganisation : The Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits

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Titel: The Journal of Neuroscience
  Andere : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Kurztitel : J. Neurosci.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Washington, DC : Society of Neuroscience
Seiten: - Band / Heft: 40 (38) Artikelnummer: - Start- / Endseite: 7318 - 7325 Identifikator: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1