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  An encryption-decryption framework for validating single-particle imaging

Shen, Z., Teo, C. Z. W., Ayyer, K., & Loh, N. D. (2021). An encryption-decryption framework for validating single-particle imaging. Scientific Reports, 11:. doi:10.1038/s41598-020-79589-0.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0007-0C8C-F 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000B-C769-F
資料種別: 学術論文

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s41598-020-79589-0.pdf (出版社版), 3MB
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https://hdl.handle.net/21.11116/0000-0007-DC2D-0
ファイル名:
s41598-020-79589-0.pdf
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Open Access. - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
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公開
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著作権日付:
2021
著作権情報:
© the Author(s)
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41598_2020_79589_MOESM1_ESM.pdf (付録資料), 140KB
ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-0007-DC2E-F
ファイル名:
41598_2020_79589_MOESM1_ESM.pdf
説明:
Supplementary Information
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URL:
https://arxiv.org/abs/2007.03054 (プレプリント)
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作成者

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 作成者:
Shen, Z.1, 2, 著者
Teo, C. Z. W.1, 2, 著者
Ayyer, K.3, 4, 著者           
Loh, N. D.1, 2, 5, 著者
所属:
1Centre for Bio-imaging Sciences, National University of Singapore, ou_persistent22              
2Department of Physics, National University of Singapore, ou_persistent22              
3Computational Nanoscale Imaging, Condensed Matter Dynamics Department, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_3012829              
4Center for Free-Electron Laser Science, ou_persistent22              
5Department of Biological Sciences, National University of Singapore, ou_persistent22              

内容説明

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 要旨: We propose an encryption–decryption framework for validating diffraction intensity volumes reconstructed using single-particle imaging (SPI) with X-ray free-electron lasers (XFELs) when the ground truth volume is absent. This conceptual framework exploits each reconstructed volumes’ ability to decipher latent variables (e.g. orientations) of unseen sentinel diffraction patterns. Using this framework, we quantify novel measures of orientation disconcurrence, inconsistency, and disagreement between the decryptions by two independently reconstructed volumes. We also study how these measures can be used to define data sufficiency and its relation to spatial resolution, and the practical consequences of focusing XFEL pulses to smaller foci. This conceptual framework overcomes critical ambiguities in using Fourier Shell Correlation (FSC) as a validation measure for SPI. Finally, we show how this encryption-decryption framework naturally leads to an information-theoretic reformulation of the resolving power of XFEL-SPI, which we hope will lead to principled frameworks for experiment and instrument design.

資料詳細

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言語: eng - English
 日付: 2020-08-282020-11-172021-01-13
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): arXiv: 2007.03054
DOI: 10.1038/s41598-020-79589-0
 学位: -

関連イベント

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訴訟

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Project information

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Project name : N.D.L. and Z.S. acknowledge the support of the National University of Singapore startup grant; C.Z.W.T. thanks the support of the Singapore National Research Foundation (NRF-CRP16-2015-05). The authors are grateful to Benedikt Daurer, Andrew Martin, Filipe Maia, and Tomas Ekeberg for stimulating discussions.
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Funding organization : -

出版物 1

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出版物名: Scientific Reports
  省略形 : Sci. Rep.
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: London, UK : Nature Publishing Group
ページ: - 巻号: 11 通巻号: 971 開始・終了ページ: - 識別子(ISBN, ISSN, DOIなど): ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322