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  Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis

Koenig, J., Abler, B., Agartz, I., Åkerstedt, T., Andreassen, O. A., Anthony, M., et al. (2021). Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis. Psychophysiology, 58(7): e13688. doi:10.1111/psyp.13688.

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 Urheber:
Koenig, Julian, Autor
Abler, Birgit, Autor
Agartz, Ingrid, Autor
Åkerstedt, Torbjörn, Autor
Andreassen, Ole A., Autor
Anthony, Mia, Autor
Bär, Karl‐Jürgen, Autor
Bertsch, Katja, Autor
Brown, Rebecca C., Autor
Brunner, Romuald, Autor
Carnevali, Luca, Autor
Critchley, Hugo D., Autor
Cullen, Kathryn R., Autor
Geus, Eco J. C., Autor
Cruz, Feliberto, Autor
Dziobek, Isabel, Autor
Ferger, Marc D., Autor
Fischer, Håkan, Autor
Flor, Herta, Autor
Gaebler, Michael1, Autor           
Gianaros, Peter J, AutorGiummarra, Melita J., AutorGreening, Steven G., AutorGuendelman, Simon, AutorHeathers, James A. J., AutorHerpertz, Sabine C., AutorHu, Mandy X., AutorJentschke, Sebastian, AutorKaess, Michael, AutorKaufmann, Tobias, AutorKlimes‐Dougan, Bonnie, AutorKoelsch, Stefan, AutorKrauch, Marlene, AutorKumral, Deniz1, Autor           Lamers, Femke, AutorLee, Tae‐Ho, AutorLekander, Mats, AutorLin, Feng, AutorLotze, Martin, AutorMakovac, Elena, AutorMancini, Matteo, AutorMancke, Falk, AutorMånsson, Kristoffer N. T., AutorManuck, Stephen B., AutorMather, Mara, AutorMeeten, Frances, AutorMin, Jungwon, AutorMueller, Bryon, AutorMuench, Vera, AutorNees, Frauke, AutorNga, Lin, AutorNilsonne, Gustav, AutorOrdonez Acuna, Daniela, AutorOsnes, Berge, AutorOttaviani, Cristina, AutorPenninx, Brenda W. J. H., AutorPonzio, Allison, AutorPoudel, Govinda R., AutorReinelt, Janis1, Autor           Ren, Ping, AutorSakaki, Michiko, AutorSchumann, Andy, AutorSørensen, Lin, AutorSpecht, Karsten, AutorStraub, Joana, AutorTamm, Sandra, AutorThai, Michelle, AutorThayer, Julian F., AutorUbani, Benjamin, AutorMee, Denise J., AutorVelzen, Laura S., AutorVentura‐Bort, Carlos, AutorVillringer, Arno1, Autor           Watson, David R., AutorWei, Luqing, AutorWendt, Julia, AutorSchreiner, Melinda Westlund, AutorWestlye, Lars T., AutorWeymar, Mathias, AutorWinkelmann, Tobias, AutorWu, Guo‐Rong, AutorYoo, Hyun Joo, AutorQuintana, Daniel S., Autor mehr..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Inhalt

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Schlagwörter: Aging; Autonomic nervous system; Cortical thickness; Heart rate; Heart rate variability; Sex
 Zusammenfassung: Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega‐analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.

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Sprache(n): eng - English
 Datum: 2020-07-272020-01-242020-07-272020-10-102021-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1111/psyp.13688
Anderer: epub 2020
PMID: 33037836
 Art des Abschluß: -

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Projektname : -
Grant ID : DE170100726
Förderprogramm : -
Förderorganisation : Australian Research Council
Projektname : -
Grant ID : WE 4801/3‐1
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Projekt DEAL

Quelle 1

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Titel: Psychophysiology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY [etc.] : Blackwell Publishing Inc. [etc.]
Seiten: - Band / Heft: 58 (7) Artikelnummer: e13688 Start- / Endseite: - Identifikator: ISSN: 0048-5772
CoNE: https://pure.mpg.de/cone/journals/resource/954925334698