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  Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis

Koenig, J., Abler, B., Agartz, I., Åkerstedt, T., Andreassen, O. A., Anthony, M., et al. (2020). Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis. Psychophysiology. doi:10.1111/psyp.13688.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-657E-B Version Permalink: http://hdl.handle.net/21.11116/0000-0007-657F-A
Genre: Journal Article

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Koenig, Julian, Author
Abler, Birgit, Author
Agartz, Ingrid, Author
Åkerstedt, Torbjörn, Author
Andreassen, Ole A., Author
Anthony, Mia, Author
Bär, Karl‐Jürgen, Author
Bertsch, Katja, Author
Brown, Rebecca C., Author
Brunner, Romuald, Author
Carnevali, Luca, Author
Critchley, Hugo D., Author
Cullen, Kathryn R., Author
Geus, Eco J. C., Author
Cruz, Feliberto, Author
Dziobek, Isabel, Author
Ferger, Marc D., Author
Fischer, Håkan, Author
Flor, Herta, Author
Gaebler, Michael1, Author              
Gianaros, Peter J, AuthorGiummarra, Melita J., AuthorGreening, Steven G., AuthorGuendelman, Simon, AuthorHeathers, James A. J., AuthorHerpertz, Sabine C., AuthorHu, Mandy X., AuthorJentschke, Sebastian, AuthorKaess, Michael, AuthorKaufmann, Tobias, AuthorKlimes‐Dougan, Bonnie, AuthorKoelsch, Stefan, AuthorKrauch, Marlene, AuthorKumral, Deniz1, Author              Lamers, Femke, AuthorLee, Tae‐Ho, AuthorLekander, Mats, AuthorLin, Feng, AuthorLotze, Martin, AuthorMakovac, Elena, AuthorMancini, Matteo, AuthorMancke, Falk, AuthorMånsson, Kristoffer N. T., AuthorManuck, Stephen B., AuthorMather, Mara, AuthorMeeten, Frances, AuthorMin, Jungwon, AuthorMueller, Bryon, AuthorMuench, Vera, AuthorNees, Frauke, AuthorNga, Lin, AuthorNilsonne, Gustav, AuthorOrdonez Acuna, Daniela, AuthorOsnes, Berge, AuthorOttaviani, Cristina, AuthorPenninx, Brenda W. J. H., AuthorPonzio, Allison, AuthorPoudel, Govinda R., AuthorReinelt, Janis1, Author              Ren, Ping, AuthorSakaki, Michiko, AuthorSchumann, Andy, AuthorSørensen, Lin, AuthorSpecht, Karsten, AuthorStraub, Joana, AuthorTamm, Sandra, AuthorThai, Michelle, AuthorThayer, Julian F., AuthorUbani, Benjamin, AuthorMee, Denise J., AuthorVelzen, Laura S., AuthorVentura‐Bort, Carlos, AuthorVillringer, Arno1, Author              Watson, David R., AuthorWei, Luqing, AuthorWendt, Julia, AuthorSchreiner, Melinda Westlund, AuthorWestlye, Lars T., AuthorWeymar, Mathias, AuthorWinkelmann, Tobias, AuthorWu, Guo‐Rong, AuthorYoo, Hyun Joo, AuthorQuintana, Daniel S., Author more..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Aging; Autonomic nervous system; Cortical thickness; Heart rate; Heart rate variability; Sex
 Abstract: Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega‐analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.

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Language(s): eng - English
 Dates: 2020-07-272020-01-242020-07-272020-10-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/psyp.13688
Other: online ahead of print
PMID: 33037836
 Degree: -

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Project name : -
Grant ID : DE170100726
Funding program : -
Funding organization : Australian Research Council
Project name : -
Grant ID : DFG WE 4801/3‐1
Funding program : -
Funding organization : German Research Foundation

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Title: Psychophysiology
Source Genre: Journal
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Publ. Info: New York, NY [etc.] : Blackwell Publishing Inc. [etc.]
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0048-5772
CoNE: https://pure.mpg.de/cone/journals/resource/954925334698