From pyrazolones to azaindoles : evolution of active-site SHP2 inhibitors based 
on scaffold hopping and bioisosteric replacement

Mostinski, Yelena; Heynen, Guus J. J. E.; López-Alberca, Maria Pascual; Paul, Jerome; Miksche, Sandra; Radetzki, Silke; Schaller, David; Shanina, Elena; Seyffarth, Carola; Kolomeets, Yuliya; Ziebart, Nandor; de Schryver, Judith; Oestreich, Sylvia; Neuenschwander, Martin; Roske, Yvette; Heinemann, Udo; Rademacher, Christoph; Volkamer, Andrea; von Kries, Jens Peter; Birchmeier, Walter; Nazaré, Marc

doi:10.1021/acs.jmedchem.0c01265

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From pyrazolones to azaindoles : evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement

Mostinski, Y., Heynen, G. J. J. E., López-Alberca, M. P., Paul, J., Miksche, S., Radetzki, S., et al. (2020). From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement. Journal of Medicinal Chemistry, 63(23), 14780-14804. doi:10.1021/acs.jmedchem.0c01265.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-7565-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-8CA6-0

Genre: Journal Article

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Creators:
Mostinski, Yelena, Author
Heynen, Guus J. J. E., Author
López-Alberca, Maria Pascual, Author
Paul, Jerome, Author
Miksche, Sandra, Author
Radetzki, Silke, Author
Schaller, David, Author
Shanina, Elena¹, Author
Seyffarth, Carola, Author
Kolomeets, Yuliya, Author
Ziebart, Nandor, Author
de Schryver, Judith, Author
Oestreich, Sylvia, Author
Neuenschwander, Martin, Author
Roske, Yvette, Author
Heinemann, Udo, Author
Rademacher, Christoph¹, Author
Volkamer, Andrea, Author
von Kries, Jens Peter, Author
Birchmeier, Walter, Author
Nazaré, Marc, Author more..

Affiliations:
1Christoph Rademacher, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863300

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Free keywords: Cells, Inhibitors, Inhibition, Cancer, Peptides and proteins

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Language(s): eng - English

Dates: Published Online: 2020-11-19Date issued: 2020

Publication Status: Issued

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Identifiers: DOI: 10.1021/acs.jmedchem.0c01265
BibTex Citekey: doi:10.1021/acs.jmedchem.0c01265

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Title: Journal of Medicinal Chemistry

Source Genre: Journal

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Publ. Info: Washington DC : ACS Publications

Pages: - Volume / Issue: 63 (23) Sequence Number: - Start / End Page: 14780 - 14804 Identifier: ISSN: 0022-2623