English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Reliance on model-based and model-free control in obesity

Janssen, L., Mahner, F. P., Schlagenhauf, F., Deserno, L., & Horstmann, A. (2020). Reliance on model-based and model-free control in obesity. Scientific Reports, 10(1): 22433. doi:10.1038/s41598-020-79929-0.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0007-AAA5-F Version Permalink: http://hdl.handle.net/21.11116/0000-0007-AAA6-E
Genre: Journal Article

Files

show Files
hide Files
:
Janssen_2020.pdf (Publisher version), 2MB
Name:
Janssen_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Janssen, Lieneke1, 2, Author              
Mahner, Florian P.2, Author
Schlagenhauf, Florian2, 3, Author              
Deserno, Lorenz1, 2, 4, 5, 6, Author              
Horstmann, Annette1, 2, 7, Author              
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
4Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom, ou_persistent22              
5Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
6Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Würzburg, Germany, ou_persistent22              
7Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              

Content

show
hide
Free keywords: Decision; Human behaviour; Learning algorithms; Reward
 Abstract: Consuming more energy than is expended may reflect a failure of control over eating behaviour in obesity. Behavioural control arises from a balance between two dissociable strategies of reinforcement learning: model-free and model-based. We hypothesized that weight status relates to an imbalance in reliance on model-based and model-free control, and that it may do so in a linear or quadratic manner. To test this, 90 healthy participants in a wide BMI range [normal-weight (n = 31), overweight (n = 29), obese (n = 30)] performed a sequential decision-making task. The primary analysis indicated that obese participants relied less on model-based control than overweight and normal-weight participants, with no difference between overweight and normal-weight participants. In line, secondary continuous analyses revealed a negative linear, but not quadratic, relationship between BMI and model-based control. Computational modelling of choice behaviour suggested that a mixture of both strategies was shifted towards less model-based control in obese participants. Our findings suggest that obesity may indeed be related to an imbalance in behavioural control as expressed in a phenotype of less model-based control potentially resulting from enhanced reliance on model-free computations.

Details

show
hide
Language(s): eng - English
 Dates: 2019-07-192020-12-082020-12-31
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-020-79929-0
PMID: 33384425
PMC: PMC7775466
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 10 (1) Sequence Number: 22433 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322