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  A genetically encodable cell-type-specific protein synthesis inhibitor

Heumuller, M., Glock, C., Rangaraju, V., Biever, A., & Schuman, E. M. (2019). A genetically encodable cell-type-specific protein synthesis inhibitor. Nat Methods, 16(8), 699-702. doi:10.1038/s41592-019-0468-x.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-EEF9-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-B833-D
Genre: Journal Article

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2019
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This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41592-019-0468-x
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https://www.ncbi.nlm.nih.gov/pubmed/31308551 (Any fulltext)
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 Creators:
Heumuller, M., Author
Glock, C., Author
Rangaraju, V., Author
Biever, A., Author
Schuman, Erin M.1, Author           
Affiliations:
1Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              

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Free keywords: Animals Cells, Cultured *Genetic Engineering HeLa Cells Hippocampus/cytology/drug effects/*metabolism Humans Neuroglia/cytology/drug effects/metabolism Neuronal Plasticity/*drug effects Neurons/cytology/drug effects/*metabolism *Protein Biosynthesis Protein Synthesis Inhibitors/chemistry/*pharmacology Rats Synapses/drug effects/*metabolism
 Abstract: Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a genetically encodable protein synthesis inhibitor (gePSI) to achieve cell-type-specific temporal control of protein synthesis. Controlled expression of the gePSI in neurons or glia resulted in rapid, potent and reversible cell-autonomous inhibition of protein synthesis. Moreover, gePSI expression in a single neuron blocked the structural plasticity induced by single-synapse stimulation.

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 Dates: 2019-07-17
 Publication Status: Issued
 Pages: -
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 Identifiers: Other: 31308551
DOI: 10.1038/s41592-019-0468-x
ISSN: 1548-7105 (Electronic)1548-7091 (Linking)
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Project name : Specialized Ribosomes for Neuronal Protein Synthesis (NeuroRibo)
Grant ID : 743216
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis (Subproject B01)
Grant ID : 221828878
Funding program : Sonderforschungsbereiche (SFB)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : SFB 902: Molecular Principles of RNA-based Regulation
Grant ID : 161793742
Funding program : Sonderforschungsbereiche (SFB)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Nat Methods
Source Genre: Journal
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Pages: - Volume / Issue: 16 (8) Sequence Number: - Start / End Page: 699 - 702 Identifier: -