A genetically encodable cell-type-specific protein synthesis inhibitor

Heumuller, M.; Glock, C.; Rangaraju, V.; Biever, A.; Schuman, Erin M.

doi:10.1038/s41592-019-0468-x

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A genetically encodable cell-type-specific protein synthesis inhibitor

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Schuman, Erin M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/31308551
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Citation

Heumuller, M., Glock, C., Rangaraju, V., Biever, A., & Schuman, E. M. (2019). A genetically encodable cell-type-specific protein synthesis inhibitor. Nat Methods, 16(8), 699-702. doi:10.1038/s41592-019-0468-x.

Cite as: https://hdl.handle.net/21.11116/0000-0007-EEF9-5

Abstract

Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a genetically encodable protein synthesis inhibitor (gePSI) to achieve cell-type-specific temporal control of protein synthesis. Controlled expression of the gePSI in neurons or glia resulted in rapid, potent and reversible cell-autonomous inhibition of protein synthesis. Moreover, gePSI expression in a single neuron blocked the structural plasticity induced by single-synapse stimulation.