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  Abstract rules drive adaptation in the subcortical sensory pathway

Tabas, A., Mihai, P. G., Kiebel, S., Trampel, R., & von Kriegstein, K. (2020). Abstract rules drive adaptation in the subcortical sensory pathway. eLife, 9: e64501. doi:10.7554/eLife.64501.

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 Creators:
Tabas, Alejandro1, 2, Author              
Mihai, Paul Glad1, 2, Author              
Kiebel, Stefan1, 3, Author
Trampel, Robert4, Author              
von Kriegstein, Katharina1, 2, Author              
Affiliations:
1Faculty of Psychology, TU Dresden, Germany, ou_persistent22              
2Max Planck Research Group Neural Mechanisms of Human Communication, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634556              
3Centre for Tactile Internet with Human-in-the-Loop (CeTI), TU Dresden, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: IC; MGB; SSA; Human; Neuroscience; Predictive coding; Sensory processing; Thalamus
 Abstract: The subcortical sensory pathways are the fundamental channels for mapping the outside world to our minds. Sensory pathways efficiently transmit information by adapting neural responses to the local statistics of the sensory input. The long-standing mechanistic explanation for this adaptive behaviour is that neural activity decreases with increasing regularities in the local statistics of the stimuli. An alternative account is that neural coding is directly driven by expectations of the sensory input. Here, we used abstract rules to manipulate expectations independently of local stimulus statistics. The ultra-high-field functional-MRI data show that abstract expectations can drive the response amplitude to tones in the human auditory pathway. These results provide first unambiguous evidence of abstract processing in a subcortical sensory pathway. They indicate that the neural representation of the outside world is altered by our prior beliefs even at initial points of the processing hierarchy.

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Language(s): eng - English
 Dates: 2020-10-302020-12-032020-12-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.64501
PMID: 33289479
PMC: PMC7785290
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Project name : Horizon 2020
Grant ID : 647051
Funding program : -
Funding organization : European Research Council
Project name : -
Grant ID : EXC 2050/1
Funding program : (390696704)
Funding organization : Deutsche Forschungsgemeinschaft DFG

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 9 Sequence Number: e64501 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X