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Free keywords:
Glucose; Sodium; Sugar; Plasma Membrane; Human Physiology
Abstract:
Uptake studies ofD- andL-glucose were performed on vesicles derived from brush-border and basal-lateral membranes. The uptake of the sugars into the vesicles was osmotically sensitive and independent of glucose metabolism. In brush-border vesiclesD-glucose but notL-glucose transport was Na+-dependent, was inhibited by phlorizin, and showed a transitory vesicle/medium ratio >1, in the presence of an initial Na+ gradient. Basal-lateral membranes take upD-glucose faster thanL-glucose, but theD-glucose uptake is significantly less sensitive to sodium removal and only moderately inhibited by phlorizin as compared to the brush-border fraction.
