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  Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [Ca2+]i increase in rat pancreatic acinar cells

Pröfrock, A., Piiper, A., Eckhardt, L., & Schulz, I. (1991). Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [Ca2+]i increase in rat pancreatic acinar cells. Biochemical and Biophysical Research Communications, 180(2), 900-906. doi:10.1016/S0006-291X(05)81150-7.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-67DF-A Version Permalink: https://hdl.handle.net/21.11116/0000-0008-67E0-7
Genre: Journal Article

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 Creators:
Pröfrock, André1, Author           
Piiper, Albrecht1, Author           
Eckhardt, Luise1, Author           
Schulz, Irene1, Author           
Affiliations:
1Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068297              

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 Abstract: We have studied the effects of epidermal growth factor (EGF) on both cholecystokinin octapeptide (CCK-OP)-induced inositol-1,4,5 trisphosphate (IP) production and on cytosolic free calcium concentrations [Ca2+]i by fluorescence measurements in fura-2-loaded pancreatic acini. Our data show that EGF inhibits CCK-OP induced IP3 production by 40 ± 9 % and decreases CCK-OP induced rise in cytosolic Ca2+ by 41 ± 9 %. These data indicate that activation of EGF receptors leads to inhibition of CCK-OP induced stimulation of phospholipase C (PLC).

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Language(s): eng - English
 Dates: 1991-09-102005-04-041991-10-31
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S0006-291X(05)81150-7
PMID: 1953760
 Degree: -

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Title: Biochemical and Biophysical Research Communications
  Other : Biochem. Biophys. Res. Commun.
Source Genre: Journal
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Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 180 (2) Sequence Number: - Start / End Page: 900 - 906 Identifier: ISSN: 0006-291X
CoNE: https://pure.mpg.de/cone/journals/resource/954922652205_1