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  Membrane-embedded TSPO: an NMR view

Rivière, G., Jaipuria, G., Andreas, L. B., Leonov, A., Giller, K., Becker, S., et al. (2021). Membrane-embedded TSPO: an NMR view. European Biophysics Journal, 50(2), 173-180. doi:10.1007/s00249-020-01487-0.

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 Creators:
Rivière, G., Author
Jaipuria, G., Author
Andreas, L. B.1, Author              
Leonov, A.2, Author              
Giller, K.2, Author              
Becker, S.2, Author              
Zweckstetter, M.3, Author              
Affiliations:
1Research Group of Solid State NMR Spectroscopy-2, MPI for Biophysical Chemistry, Max Planck Society, ou_2396693              
2Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              
3Research Group of Protein Structure Determination using NMR, MPI for biophysical chemistry, Max Planck Society, ou_578571              

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Free keywords: Cholesterol; Dynamics; Solid-state NMR; Structure; Lipid; Membrane protein; Neurodegeneration; TSPO
 Abstract: Translocator Protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein commonly used as a biomarker for neuroinflammation and is also a potential therapeutic target in neurodegenerative diseases. Despite intensive research efforts, the function of TSPO is still largely enigmatic. Deciphering TSPO structure in the native lipid environment is essential to gain insight into its cellular activities and to design improved diagnostic and therapeutic ligands. Here, we discuss the influence of lipid composition on the structure of mammalian TSPO embedded into lipid bilayers on the basis of solid-state NMR experiments. We further highlight that cholesterol can influence both the tertiary and quaternary TSPO structure and also influence TSPO localization in mitochondria-associated endoplasmic reticulum membranes.

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Language(s): eng - English
 Dates: 2020-12-222021-03
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s00249-020-01487-0
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Title: European Biophysics Journal
Source Genre: Journal
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Pages: - Volume / Issue: 50 (2) Sequence Number: - Start / End Page: 173 - 180 Identifier: -