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  Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke

Kufner, A., Khalil, A., Galinovic, I., Kellner, E., Mekle, R., Rackoll, T., et al. (2021). Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 41(10), 2617-2627. doi:10.1177/0271678X211010071.

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 Creators:
Kufner, Anna1, 2, 3, Author
Khalil, Ahmed1, 3, 4, 5, Author              
Galinovic, Ivana1, Author
Kellner, Elias6, Author
Mekle, Ralf1, Author
Rackoll, Torsten1, 7, 8, Author
Boehm-Sturm, Philipp1, 9, 10, Author
Fiebach, Jochen B1, 2, Author
Flöel, Agnes1, 11, 12, Author
Ebinger, Martin1, 13, Author
Endres, Matthias1, 2, 3, 8, 14, 15, Author
Nave, Alexander H1, 2, 3, 14, Author
Affiliations:
1Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
3Berlin Institute of Health (BIH), Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Department of Radiology, University Medical Center, Germany, ou_persistent22              
7QUEST Center for Transforming Biomedical Research, Berlin Institute of Health (BIH), Germany, ou_persistent22              
8NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
9Core Facility 7T Experimental MRIs, NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
10Department of Experimental Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
11Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
12German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany, ou_persistent22              
13Department of Neurology, Medical Park Berlin, Germany, ou_persistent22              
14German Centre for Cardiovascular Research, Berlin, Germany, ou_persistent22              
15German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany, ou_persistent22              

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Free keywords: Angiogenesis; Ischemic stroke; Microvasculature; Perfusion; Vessel size imaging
 Abstract: MRI-based vessel size imaging (VSI) allows for in-vivo assessment of cerebral microvasculature and perfusion. This exploratory analysis of vessel size (VS) and density (Q; both assessed via VSI) in the subacute phase of ischemic stroke involved sixty-two patients from the BAPTISe cohort ('Biomarkers And Perfusion--Training-Induced changes after Stroke') nested within a randomized controlled trial (intervention: 4-week training vs. relaxation). Relative VS, Q, cerebral blood volume (rCBV) and -flow (rCBF) were calculated for: ischemic lesion, perilesional tissue, and region corresponding to ischemic lesion on the contralateral side (mirrored lesion). Linear mixed-models detected significantly increased rVS and decreased rQ within the ischemic lesion compared to the mirrored lesion (coefficient[standard error]: 0.2[0.08] p = 0.03 and -1.0[0.3] p = 0.02, respectively); lesion rCBF and rCBV were also significantly reduced. Mixed-models did not identify time-to-MRI, nor training as modifying factors in terms of rVS or rQ up to two months post-stroke. Larger lesion VS was associated with larger lesion volumes (β 34, 95%CI 6.2-62; p = 0.02) and higher baseline NIHSS (β 3.0, 95%CI 0.49-5.3;p = 0.02), but was not predictive of six-month outcome. In summary, VSI can assess the cerebral microvasculature and tissue perfusion in the subacute phases of ischemic stroke, and may carry relevant prognostic value in terms of lesion volume and stroke severity.

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Language(s): eng - English
 Dates: 2021-04-172021-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1177/0271678X211010071
PMID: 33866849
Other: epub 2021
 Degree: -

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 41 (10) Sequence Number: - Start / End Page: 2617 - 2627 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202