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Abstract:
Macromolecule-suppressed GABA-editing with symmetrical suppression is often preferred over conventional GABA-editing due to its greater specificity. However, this pulse sequence is more sensitive to magnetic field instabilities than conventional GABA-editing. This leads to macromolecule contamination in the edited GABA signal. Here, we combine metabolite cycling with J-difference (MC-MEGA) editing to allow for prospective volume-localized frequency correction at each repetition time without the acquisition of additional water reference transients. We show here that prospective MC-MEGA reduces B0 field instability relative to intermittent prospective frequency correction with water suppressed (WS) MEGA and reduces macromolecule contamination and subtraction artifacts.
