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  Reduction of 7T CEST scan time and evaluation by L1-regularised linear projections

Fabian, M., Glang, F., Khakzar, K., Mennecke, A., German, A., Schmidt, M., et al. (2021). Reduction of 7T CEST scan time and evaluation by L1-regularised linear projections. Poster presented at 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).

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Fabian, MS, Author
Glang, F1, 2, Author              
Khakzar, KM, Author
Mennecke, AB, Author
German, A, Author
Schmidt, M, Author
Kasper, B, Author
Dörfler, A, Author
Laun, FB, Author
Zaiss, M1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Measurement and evaluation of multi-parametric CEST protocols requires complex and time consuming processing for correction of field inhomogeneities and contrast generation. In this work, we expand the linear projection approach for mapping motion corrected 7T CEST data directly to Lorentzian target parameters by L1-regularisation. This translates to subsampling in the frequency offset domain, resulting in reduced acquisition time. The method generalizes from healthy subject training data to unseen healthy test data and a tumor patient dataset. The L1-regularized linear projection approach integrates shortcutting of B0 and B1 correction, denoising, and Lorentzian fitting. It enforces sparsity of required frequency offsets.

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 Dates: 2021-05
 Publication Status: Published online
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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1452 Start / End Page: - Identifier: -