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  Identifying the origin of local flexibility in a carbohydrate polymer

Anggara, K., Zhu, Y., Fittolani, G., Yu, Y., Tyrikos-Ergas, T., Delbianco, M., et al. (2021). Identifying the origin of local flexibility in a carbohydrate polymer. Proceedings of the National Academy of Sciences of the United States of America, 118(23): e2102168118. doi:10.1073/pnas.2102168118.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-A82B-B Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-A82C-A
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 Urheber:
Anggara, Kelvin, Autor
Zhu, Yuntao1, Autor           
Fittolani, Giulio2, Autor           
Yu, Yang2, Autor           
Tyrikos-Ergas, Theodore2, Autor           
Delbianco, Martina2, Autor           
Rauschenbach, Stephan, Autor
Abb, Sabine, Autor
Seeberger, Peter H.1, Autor           
Kern, Klaus, Autor
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
2Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2559692              

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Schlagwörter: structure-property relationship; glycan flexibility; automated synthesis
 Zusammenfassung: The monomer sequence dictates the structure and properties of natural polymers. Such a structure property relationship is well known for polypeptides and polynucleotides but not for polysaccharides, the most abundant biopolymers on Earth. Here, we establish the structure property relationship for a polysaccharide at the atomic level by determining molecular flexibility of carbohydrate chains with defined sequences. The chain flexibility can be engineered one linkage at a time by chemical substitution and conformation change, highlighting how the primary and secondary structures of a carbohydrate dictate its flexibility a critical observable in the de novo design of carbohydrate materials. Our approach can be extended to establish the structure property relationship at the atomic level of any molecule that can be electrosprayed.Correlating the structures and properties of a polymer to its monomer sequence is key to understanding how its higher hierarchy structures are formed and how its macroscopic material properties emerge. Carbohydrate polymers, such as cellulose and chitin, are the most abundant materials found in nature whose structures and properties have been characterized only at the submicrometer level. Here, by imaging single-cellulose chains at the nanoscale, we determine the structure and local flexibility of cellulose as a function of its sequence (primary structure) and conformation (secondary structure). Changing the primary structure by chemical substitutions and geometrical variations in the secondary structure allow the chain flexibility to be engineered at the single-linkage level. Tuning local flexibility opens opportunities for the bottom-up design of carbohydrate materials.All data needed to evaluate the conclusion in the paper are present in the paper or SI Appendix.

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Sprache(n): eng - English
 Datum: 2021-06-012021
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1073/pnas.2102168118
BibTex Citekey: Anggarae2102168118
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : PNAS
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : Proc. Natl. Acad. Sci. U. S. A.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 118 (23) Artikelnummer: e2102168118 Start- / Endseite: - Identifikator: ISSN: 0027-8424