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  Auditory thalamus dysfunction and pathophysiology in tinnitus: A predictive network hypothesis

Brinkmann, P., Kotz, S. A., Smit, J. V., Janssen, M. L. F., & Schwartze, M. (2021). Auditory thalamus dysfunction and pathophysiology in tinnitus: A predictive network hypothesis. Brain Structure & Function, 226(6), 1659-1676. doi:10.1007/s00429-021-02284-x.

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 Creators:
Brinkmann, Pia1, Author
Kotz, Sonja A.1, 2, Author              
Smit, Jasper V.3, Author
Janssen, Marcus L. F.4, 5, Author
Schwartze, Michael1, Author              
Affiliations:
1Department of Neuropsychology and Psychopharmacology, Maastricht University, the Netherlands, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
3Zuyderland Medical Center, Heerlen, the Netherlands, ou_persistent22              
4Department of Clinical Neurophysiology, Maastricht University, the Netherlands, ou_persistent22              
5School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands, ou_persistent22              

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Free keywords: MGB; Medial geniculate nucleus; Prediction; Temporal processing; Tinnitus
 Abstract: Tinnitus is the perception of a 'ringing' sound without an acoustic source. It is generally accepted that tinnitus develops after peripheral hearing loss and is associated with altered auditory processing. The thalamus is a crucial relay in the underlying pathways that actively shapes processing of auditory signals before the respective information reaches the cerebral cortex. Here, we review animal and human evidence to define thalamic function in tinnitus. Overall increased spontaneous firing patterns and altered coherence between the thalamic medial geniculate body (MGB) and auditory cortices is observed in animal models of tinnitus. It is likely that the functional connectivity between the MGB and primary and secondary auditory cortices is reduced in humans. Conversely, there are indications for increased connectivity between the MGB and several areas in the cingulate cortex and posterior cerebellar regions, as well as variability in connectivity between the MGB and frontal areas regarding laterality and orientation in the inferior, medial and superior frontal gyrus. We suggest that these changes affect adaptive sensory gating of temporal and spectral sound features along the auditory pathway, reflecting dysfunction in an extensive thalamo-cortical network implicated in predictive temporal adaptation to the auditory environment. Modulation of temporal characteristics of input signals might hence factor into a thalamo-cortical dysrhythmia profile of tinnitus, but could ultimately also establish new directions for treatment options for persons with tinnitus.

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Language(s): eng - English
 Dates: 2020-08-262021-04-212021-05-022021-07
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00429-021-02284-x
PMID: 33934235
PMC: PMC8203542
Other: epub 2021
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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
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Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 226 (6) Sequence Number: - Start / End Page: 1659 - 1676 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653