SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of 
proximal polyadenylation sites and regulation of CFIm levels.

Schwich, Oliver D; Blümel, Nicole; Keller, Mario; Wegener, Marius; Setty, Samarth Thonta; Brunstein, Melinda Elaine; Poser, Ina; Mozos, Igor Ruiz De Los; Suess, Beatrix; Münch, Christian; McNicoll, François; Zarnack, Kathi; Müller-McNicoll, Michaela

doi:10.1186/s13059-021-02298-y

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SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.

Schwich, O. D., Blümel, N., Keller, M., Wegener, M., Setty, S. T., Brunstein, M. E., et al. (2021). SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Genome biology, 22(1): 82. doi:10.1186/s13059-021-02298-y.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-DB13-C Version Permalink: https://hdl.handle.net/21.11116/0000-0008-DB14-B

Genre: Journal Article

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Creators:
Schwich, Oliver D, Author
Blümel, Nicole, Author
Keller, Mario, Author
Wegener, Marius, Author
Setty, Samarth Thonta, Author
Brunstein, Melinda Elaine, Author
Poser, Ina¹, Author
Mozos, Igor Ruiz De Los, Author
Suess, Beatrix, Author
Münch, Christian, Author
McNicoll, François, Author
Zarnack, Kathi, Author
Müller-McNicoll, Michaela, Author

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1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692

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Abstract: Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which determines the length of their 3' untranslated regions (3'UTRs). We have recently shown that SRSF3 and SRSF7, two closely related SR proteins, connect APA with mRNA export. The mechanism underlying APA regulation by SRSF3 and SRSF7 remained unknown.

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Dates: Date issued: 2021-03-11

Publication Status: Issued

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Identifiers: DOI: 10.1186/s13059-021-02298-y
Other: cbg-8033
PMID: 33706811

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Title: Genome biology

Other : Genome Biol

Source Genre: Journal

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Pages: - Volume / Issue: 22 (1) Sequence Number: 82 Start / End Page: - Identifier: -