SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of 
proximal polyadenylation sites and regulation of CFIm levels.

Schwich, Oliver D; Blümel, Nicole; Keller, Mario; Wegener, Marius; Setty, Samarth Thonta; Brunstein, Melinda Elaine; Poser, Ina; Mozos, Igor Ruiz De Los; Suess, Beatrix; Münch, Christian; McNicoll, François; Zarnack, Kathi; Müller-McNicoll, Michaela

doi:10.1186/s13059-021-02298-y

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SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels.

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Poser, Ina
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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引用

Schwich, O. D., Blümel, N., Keller, M., Wegener, M., Setty, S. T., Brunstein, M. E., Poser, I., Mozos, I. R. D. L., Suess, B., Münch, C., McNicoll, F., Zarnack, K., & Müller-McNicoll, M. (2021). SRSF3 and SRSF7 modulate 3'UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels. Genome biology, 22(1):. doi:10.1186/s13059-021-02298-y.

引用: https://hdl.handle.net/21.11116/0000-0008-DB13-C

要旨

Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which determines the length of their 3' untranslated regions (3'UTRs). We have recently shown that SRSF3 and SRSF7, two closely related SR proteins, connect APA with mRNA export. The mechanism underlying APA regulation by SRSF3 and SRSF7 remained unknown.