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  Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 9.4T

Tuzzi, E., Pohmann, R., Loktyushin, A., Laske, C., Scheffler, K., & Hagberg, G. (2021). Cortical ß-amyloid plaque load detection using QSM in Alzheimer’s patients at 9.4T. In 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).

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 Creators:
Tuzzi, E1, 2, Author              
Pohmann, R1, 2, Author              
Loktyushin, A1, 2, Author              
Laske, C, Author
Scheffler, K1, 2, Author              
Hagberg, GE1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Beta-amyloid (Aβ) plaques are characteristic of Alzheimer’s Disease (AD) brain and cause effects which can be detected by QSM. It has been shown that cortical plaque-load could be used to distinguish AD patients from healthy controls (HC) using ultra-high spatial resolution QSM at ultra-high-field (9.4 and 14.1T), in-vivo and ex-vivo. We aimed to extend these observations to a larger cohort of patients and controls at two different spatial resolutions. We found a significative (p<0.05) increase in plaque-load in AD compared to HC at both resolutions. Interestingly, some cortical regions also showed greater (p<0.05) diamagnetic effects in AD compared to HC.

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 Dates: 2021-05
 Publication Status: Published online
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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
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Start-/End Date: 2021-05-15 - 2021-05-20

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Title: 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0321 Start / End Page: - Identifier: -