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  Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies

Jung, S., Fuchs, N., Johe, P., Wagner, A., Diehl, E., Yuliani, T., et al. (2021). Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies. Journal of Medicinal Chemistry, 64(16), 12322-12358. doi:10.1021/acs.jmedchem.1c01002.

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 Creators:
Jung, Sascha1, 2, Author
Fuchs, Natalie1, Author
Johe, Patrick1, Author
Wagner, Annika3, 4, 5, Author
Diehl, Erika3, Author
Yuliani, Tri6, 7, Author
Zimmer, Collin1, Author
Barthels, Fabian1, Author
Zimmermann, Robert A.1, Author
Klein, Philipp8, Author
Waigel, Waldemar9, Author
Meyr, Jessica9, Author
Opatz, Till8, Author
Tenzer, Stefan10, Author
Distler, Ute10, Author
Räder, Hans Joachim11, Author           
Kersten, Christian1, Author
Engels, Bernd9, Author
Hellmich, Ute A.3, 4, 5, 12, Author
Klein, Jochen6, Author
Schirmeister, Tanja1, Author more..
Affiliations:
1Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci IPBS, Mainz, Germany, ou_persistent22              
2TU Dortmund, Fac Chem & Chem Biol, Dortmund, Germany, ou_persistent22              
3Johannes Gutenberg Univ Mainz, Dept Chem, Biochem Sect, Mainz, Germany, ou_persistent22              
4Friedrich Schiller Univ, Inst Organ Chem & Macromol Chem IOMC, Germany, ou_persistent22              
5Friedrich Schiller Univ Jena, Cluster Excellence Balance Microverse, Jena, Germany, ou_persistent22              
6Goethe Univ, Inst Pharmacol & Clin Pharm, Frankfurt, Germany, ou_persistent22              
7Indonesian Inst Sci LIPI, Res Ctr Chem, Gd 452 Kawasan PUSPIPTEK, Tangerang Selatan, Indonesia, ou_persistent22              
8Johannes Gutenberg Univ Mainz, Dept Chem, Organ Chem Sect, Mainz, Germany, ou_persistent22              
9Julius Maximilians Univ, Dept Phys & Theoret Chem, Würzburg, Germany, ou_persistent22              
10Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Immunol, Mainz, Germany, ou_persistent22              
11Dept. Weil: Synthesis of Macromolecules, MPI for Polymer Research, Max Planck Society, ou_2301691              
12Goethe Univ, Ctr Biomol Magnet Resonance BMRZ, Frankfurt, Germany, ou_persistent22              

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Language(s): eng - English
 Dates: 2021-08-112021-08-26
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1021/acs.jmedchem.1c01002
 Degree: -

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Title: Journal of Medicinal Chemistry
Source Genre: Journal
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Publ. Info: Washington DC : ACS Publications
Pages: - Volume / Issue: 64 (16) Sequence Number: - Start / End Page: 12322 - 12358 Identifier: ISSN: 0022-2623
CoNE: https://pure.mpg.de/cone/journals/resource/110992357271168