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  Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

Haaker, J., Maren, S., Marta, A., Merz, C. J., Richter, J., Helene, R. S., et al. (2019). Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 107, 329-345. doi:10.1016/j.neubiorev.2019.09.020.

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 Creators:
Haaker, Jan, Author
Maren, Stephen, Author
Marta, Andreatta, Author
Merz, Christian J., Author
Richter, Jan, Author
Helene, Richter S., Author
Shira, Meir Drexler, Author
Lange, Maren D., Author
Kay, Jungling, Author
Nees, Frauke, Author
Seidenbecher, Thomas, Author
Fullana, Miquel A., Author
Wotjak, Carsten T.1, Author           
Lonsdorf, Tina B., Author
Affiliations:
1RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040295              

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 Abstract: Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.

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 Dates: 20192019
 Publication Status: Issued
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Title: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Source Genre: Journal
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Pages: - Volume / Issue: 107 Sequence Number: - Start / End Page: 329 - 345 Identifier: ISSN: 0149-7634