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  Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference

Castro Alvarez, J. J., Revel, M., Carrasco Sala, J., Cléard, F., Pauli, D., Hilgers, V., et al. (2021). Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference. PLoS Genetics, 17(11): e1009843. doi:10.1371/journal.pgen.1009843.

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Castro Alvarez et al. 2021.pdf (Verlagsversion), 3MB
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 Urheber:
Castro Alvarez, Javier J.1, Autor
Revel, Maxime1, Autor
Carrasco Sala, Judit2, Autor           
Cléard, Fabienne1, Autor
Pauli, Daniel1, Autor
Hilgers, Valérie2, Autor           
Karch, François1, Autor
Maeda, Robert K.1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Department Independent Research Groups, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243640              

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 Zusammenfassung: Intergenic transcription is a common feature of eukaryotic genomes and performs important and diverse cellular functions. Here, we investigate the iab-8 ncRNA from the Drosophila Bithorax Complex and show that this RNA is able to repress the transcription of genes located at its 3’ end by a sequence-independent, transcriptional interference mechanism. Although this RNA is expressed in the early epidermis and CNS, we find that its repressive activity is limited to the CNS, where, in wild-type embryos, it acts on the Hox gene, abd-A, located immediately downstream of it. The CNS specificity is achieved through a 3’ extension of the transcript, mediated by the neuronal-specific, RNA-binding protein, ELAV. Loss of ELAV activity eliminates the 3’ extension and results in the ectopic activation of abd-A. Thus, a tissue-specific change in the length of a ncRNA is used to generate a precise pattern of gene expression in a higher eukaryote.

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Sprache(n): eng - English
 Datum: 2021-11-15
 Publikationsstatus: Online veröffentlicht
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1371/journal.pgen.1009843
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Titel: PLoS Genetics
  Andere : PLoS Genet.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: San Francisco, CA : Public Library of Science
Seiten: - Band / Heft: 17 (11) Artikelnummer: e1009843 Start- / Endseite: - Identifikator: ISSN: 1553-7390
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000017180