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  Relationship between regional white matter hyperintensities and alpha oscillations in older adults

Kumral, D., Cesnaite, E., Beyer, F., Hofmann, S., Hensch, T., Sander, C., et al. (2021). Relationship between regional white matter hyperintensities and alpha oscillations in older adults. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2021.10.006.

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 Creators:
Kumral, Deniz1, 2, 3, Author              
Cesnaite, Elena1, Author              
Beyer, Frauke1, 4, Author              
Hofmann, Simon1, Author              
Hensch, Tilman5, 6, 7, Author
Sander, Christian5, 6, Author
Hegerl, Ulrich8, Author
Haufe, Stefan9, 10, Author
Villringer, Arno1, 11, Author              
Witte, A. Veronica1, 4, 11, Author              
Nikulin, Vadim V.1, 12, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychology, Albert Ludwigs University Freiburg, Germany, ou_persistent22              
3Department of Clinical Psychology and Psychotherapy, Albert Ludwigs University Freiburg, Germany, ou_persistent22              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
6Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
7International University, Erfurt, Germany, ou_persistent22              
8Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Goethe University, Frankfurt, Germany, ou_persistent22              
9Berlin Center for Advanced Neuroimaging (BCAN), Charité University Medicine Berlin, Germany, ou_persistent22              
10Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              
11Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
12Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              

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Free keywords: EEG; MRI; White matter hyperintensity; Aging; Alpha power; Resting-state
 Abstract: Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N=907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and LRTC. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMH affecting a spatial organization of alpha sources.

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Language(s): eng - English
 Dates: 2021-09-222020-10-022021-10-122021-10-20
 Publication Status: Published online
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Project name : -
Grant ID : 758985
Funding program : Horizon 2020
Funding organization : European Union

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
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Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902