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  Motor sequences; separating the sequence from the motor: A longitudinal rsfMRI study

Jäger, A.-T., Huntenburg, J. M., Tremblay, S. A., Schneider, U., Grahl, S., Huck, J., et al. (2022). Motor sequences; separating the sequence from the motor: A longitudinal rsfMRI study. Brain Structure & Function, 227(3), 793-807. doi:10.1007/s00429-021-02412-7.

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 Creators:
Jäger, Anna-Thekla1, 2, Author              
Huntenburg, Julia M.3, Author
Tremblay, Stefanie A.4, 5, Author
Schneider, Uta1, Author
Grahl, Sophia6, Author
Huck, Julia4, Author
Tardif, Christine L.7, 8, Author
Villringer, Arno1, 2, 9, 10, 11, Author              
Gauthier, Claudine J.4, 5, Author
Bazin, Pierre-Louis1, 12, Author              
Steele, Christopher1, 13, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
3Neuroscience Programme, Champalimaud Research, Lisbon, Portugal, ou_persistent22              
4PERFORM Center, Concordia University, Montréal, QC, Canada, ou_persistent22              
5Montreal Heart Institute, QC, Canada, ou_persistent22              
6Clinic of Neurology, TU Munich, Germany, ou_persistent22              
7Institute of Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
8Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
11Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
12Faculty of Social and Behavioural Science, Cognitive Science Center Amsterdam, University of Amsterdam, the Netherlands, ou_persistent22              
13Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              

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Free keywords: Motor sequence learning; Sequence specificity; rsfMRI
 Abstract: In motor learning, sequence specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting state functional connectivity after sequence-specific motor learning are less well understood. Previous research has established that plastic changes following motor learning can be divided into stages including fast learning, slow learning and retention. A description of how resting state functional connectivity after sequence-specific motor sequence learning (MSL) develops across these stages is missing. This study aimed to identify plastic alterations in whole-brain functional connectivity after learning a complex motor sequence by contrasting an active group who learned a complex sequence with a control group who performed a control task matched for motor execution. Resting state fMRI and behavioural performance were collected in both groups over the course of 5 consecutive training days and at follow-up after 12 days to encompass fast learning, slow learning, overall learning and retention. Between-group interaction analyses showed sequence-specific decreases in functional connectivity during overall learning in the right supplementary motor area (SMA). We found that connectivity changes in a key region of the motor network, the superior parietal cortex (SPC) were not a result of sequence-specific learning but were instead linked to motor execution. Our study confirms the sequence-specific role of SMA that has previously been identified in online task-based learning studies, and extends it to resting state network changes after sequence-specific MSL.

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Language(s): eng - English
 Dates: 2021-02-162021-10-082021-10-272022-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00429-021-02412-7
Other: epub 2021
PMID: 34704176
 Degree: -

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Project name : -
Grant ID : RGPIN-2020-06812; RGPIN 2015-04665
Funding program : -
Funding organization : Natural Science and Engineering Research Council

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
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Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: 227 (3) Sequence Number: - Start / End Page: 793 - 807 Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653