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  Analyses of microstructural variation in the human striatum using non-negative matrix factorization

Robert, C., Patel, R., Blostein, N., Steele, C., & Chakravarty, M. M. (2022). Analyses of microstructural variation in the human striatum using non-negative matrix factorization. NeuroImage, 246:. doi:10.1016/j.neuroimage.2021.118744.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0009-9A34-F 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000D-66B4-5
資料種別: 学術論文

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Robert_2021.pdf (出版社版), 3MB
ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-0009-9A36-D
ファイル名:
Robert_2021.pdf
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Gold
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公開
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application/pdf / [MD5]
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著作権日付:
-
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作成者

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 作成者:
Robert, Corinne1, 著者
Patel, Raihaan1, 2, 著者
Blostein, Nadia1, 3, 著者
Steele, Christopher4, 5, 著者           
Chakravarty, M. Mallar1, 2, 3, 6, 著者
所属:
1Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
2Department of Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
3Integrated Program in Neuroscience, McGill University, Montréal, QC, Canada, ou_persistent22              
4Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              

内容説明

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キーワード: Striatum; Non-negative matrix factorization; Multimodal; Microstructure; Franctional anisotropy; Mean diffusivity; T1w/T2w
 要旨: The striatum is a major subcortical connection hub that has been heavily implicated in a wide array of motor and cognitive functions. Here, we developed a normative multimodal, data-driven microstructural parcellation of the striatum using non-negative matrix factorization (NMF) based on multiple magnetic resonance imaging-based metrics (mean diffusivity, fractional anisotropy, and the ratio between T1- and T2-weighted structural scans) from the Human Connectome Project Young Adult dataset (n = 329 unrelated participants, age range: 22–35, F/M: 185/144). We further explored the biological and functional relationships of this parcellation by relating our findings to motor and cognitive performance in tasks known to involve the striatum as well as demographics. We identified 5 spatially distinct striatal components for each hemisphere. We also show the gain in component stability when using multimodal versus unimodal metrics. Our findings suggest distinct microstructural patterns in the human striatum that are largely symmetric and that relate mostly to age and sex. Our work also highlights the putative functional relevance of these striatal components to different designations based on a Neurosynth meta-analysis.

資料詳細

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言語: eng - English
 日付: 2021-11-082021-07-152021-11-182021-11-272022-02-01
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): DOI: 10.1016/j.neuroimage.2021.118744
その他: epub 2021
PMID: 34848302
 学位: -

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Project information

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Project name : -
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Funding organization : Max Planck Society
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Grant ID : RGPIN-2020-06812; DGECR-2020-00146
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Funding organization : Natural Science and Engineering Research Council (NSERC)
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Funding organization : Heart and Stroke Foundation of Canada
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Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : This are just the project information about the MPI for Human Cognitive and Brain Sciences. More information available in the paper.
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Funding program : -
Funding organization : -

出版物 1

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出版物名: NeuroImage
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Orlando, FL : Academic Press
ページ: - 巻号: 246 通巻号: 118744 開始・終了ページ: - 識別子(ISBN, ISSN, DOIなど): ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166