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  Bottom-up reconstitution of focal adhesion complexes

Schumacher, S., Vazquez Nunez, R., Biertümpfel, C., & Mizuno, N. (2021). Bottom-up reconstitution of focal adhesion complexes. The FEBS Journal. doi:10.1111/febs.16023.

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Genre: Journal Article
Subtitle : State-Of-The-Art Review

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The FEBS Journal - 2021 - Schumacher - Bottom‐up reconstitution of focal adhesion complexes.pdf (Publisher version), 3MB
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The FEBS Journal - 2021 - Schumacher - Bottom‐up reconstitution of focal adhesion complexes.pdf
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© 2021 The Authors.

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 Creators:
Schumacher, Stephanie1, Author              
Vazquez Nunez, Roberto2, Author
Biertümpfel, Christian2, Author
Mizuno, Naoko2, Author              
Affiliations:
1Conti, Elena / Structural Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565144              
2external, ou_persistent22              

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Free keywords: TALIN HEAD DOMAIN; INTEGRIN ACTIVATION; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; ACTIN-BINDING; INTRAMOLECULAR ASSOCIATION; NANOSCALE ARCHITECTURE; EXTRACELLULAR-MATRIX; VINCULIN ACTIVATION; CYTOPLASMIC DOMAINSBiochemistry & Molecular Biology; actin; integrin; PIP2; talin; vinculin;
 Abstract: Focal adhesions (FA) are large macromolecular assemblies relevant for various cellular and pathological events such as migration, polarization, and metastatic cancer formation. At FA sites at the migrating periphery of a cell, hundreds of players gather and form a network to respond to extra cellular stimuli transmitted by the integrin receptor, the most upstream component within a cell, initiating the FA signaling pathway. Numerous cellular experiments have been performed to understand the FA architecture and functions; however, their intricate network formation hampers unraveling the precise molecular actions of individual players. Here, in vitro bottom-up reconstitution presents an advantageous approach for elucidating the FA machinery and the hierarchical crosstalk of involved cellular players.

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Language(s): eng - English
 Dates: 2021-05
 Publication Status: Published online
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000656166600001
DOI: 10.1111/febs.16023
 Degree: -

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Title: The FEBS Journal
  Other : The Federation if European Biochemical Societies Journal
Source Genre: Journal
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Publ. Info: Wiley-Blackwell
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1742-464X
CoNE: https://pure.mpg.de/cone/journals/resource/954925398485