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  Single-cell delineation of lineage and genetic identity in the mouse brain

Bandler, R. C., Vitali, I., Delgado, R. N., Ho, M. C., Dvoretskova, E., Ibarra Molinas, J. S., et al. (2022). Single-cell delineation of lineage and genetic identity in the mouse brain. Nature, 601(7893), 404-409. doi:10.1038/s41586-021-04237-0.

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s41586-021-04237-0.pdf (Publisher version), 72MB
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Open access funding provided by Max Planck Society.

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 Creators:
Bandler, Rachel C.1, Author           
Vitali, Ilaria1, Author           
Delgado, R. N., Author
Ho, May C.1, Author           
Dvoretskova, Elena1, Author           
Ibarra Molinas, Josue S.1, Author           
Frazel, P. W., Author
Mohammadkhani, M., Author
Machold, R., Author
Maedler, S., Author
Liddelow, S. A., Author
Nowakowski, T. J., Author
Fishell, Gord, Author
Mayer, Christian1, Author           
Affiliations:
1Research Group: Neurogenomics / Mayer, MPI of Neurobiology, Max Planck Society, ou_3060203              

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Free keywords: expression visualization dispersion diversity mutation origin genome Science & Technology - Other Topics
 Abstract: During neurogenesis, mitotic progenitor cells lining the ventricles ofthe embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic neurons and glia(1,2). The link between developmental lineage and cell-type diversity remains an open question. Here we used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during mouse forebrain development. We quantified clonal divergence and convergence across all major cell classes postnatally, and found diverse types of GABAergic neuron that share a common lineage. Divergence of GABAergic clones occurred during embryogenesis upon cell-cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor cell level.

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Language(s): eng - English
 Dates: 2022-01-20
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:000730550300001
DOI: 10.1038/s41586-021-04237-0
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 601 (7893) Sequence Number: - Start / End Page: 404 - 409 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238