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  Zur RNA-Synthese im Verlauf der Lebercarcinogenese durch Diäthylnitrosamin / RNA-synthesis during liver carcinogenesis by diethylnitrosamine

Rajewsky, M. F. (1968). Zur RNA-Synthese im Verlauf der Lebercarcinogenese durch Diäthylnitrosamin / RNA-synthesis during liver carcinogenesis by diethylnitrosamine. Zeitschrift für Krebsforschung, 70(4), 314-319.

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 Creators:
Rajewsky, Manfred F.1, Author           
Affiliations:
1Max Planck Institute of Biophysics, Max Planck Society, ou_2068288              

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Free keywords: Animal; Body Weight; In Vitro; Liver Neoplasms; Neoplasms, Experimental; Nitrosamines; Nucleosides; Rats; RNA; RNA, Neoplasm; Tritium
 Abstract: The incorporation of 3H-cytidine (RNA synthesis) into liver explants under standardized in vitro conditions was measured during hepatocarcinogenesis by continuous oral administration of diethylnitrosamine (DENA) to adult rats. At the daily dose of 5 mg DENA per kg body weight, the median time until death with hepatocellular carcinomata was 160 days ±6%. (S.D.) in the control group; the tumour yield was 100%. 3H-cytidine incorporation, measured at 2-4 day intervals, showed an initial depression followed by a slow increase, and finally surpassed the control level after about 140 days of carcinogenesis. The results are discussed in relation to findings by other groups, especially with respect to possibly different effects, on RNA synthesis of the two related liver carcinogens DENA and N-nitroso-morpholine.

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Language(s): deu - German
 Dates: 1968-12-01
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: PMID: 4233644
 Degree: -

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Title: Zeitschrift für Krebsforschung
  Abbreviation : Z Krebsforsch
Source Genre: Journal
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Publ. Info: Berlin : Springer Verlag
Pages: - Volume / Issue: 70 (4) Sequence Number: - Start / End Page: 314 - 319 Identifier: ISSN: 0301-1585