Zur RNA-Synthese im Verlauf der Lebercarcinogenese durch Diäthylnitrosamin / 
RNA-synthesis during liver carcinogenesis by diethylnitrosamine

Rajewsky, Manfred F.

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Zur RNA-Synthese im Verlauf der Lebercarcinogenese durch Diäthylnitrosamin / RNA-synthesis during liver carcinogenesis by diethylnitrosamine

MPS-Authors

/persons/resource/persons263803

Rajewsky, Manfred F.
Max Planck Institute of Biophysics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Rajewsky, M. F. (1968). Zur RNA-Synthese im Verlauf der Lebercarcinogenese durch Diäthylnitrosamin / RNA-synthesis during liver carcinogenesis by diethylnitrosamine. Zeitschrift für Krebsforschung, 70(4), 314-319.

Cite as: https://hdl.handle.net/21.11116/0000-000A-5467-4

Abstract

The incorporation of ³H-cytidine (RNA synthesis) into liver explants under standardized in vitro conditions was measured during hepatocarcinogenesis by continuous oral administration of diethylnitrosamine (DENA) to adult rats. At the daily dose of 5 mg DENA per kg body weight, the median time until death with hepatocellular carcinomata was 160 days ±6%. (S.D.) in the control group; the tumour yield was 100%. ³H-cytidine incorporation, measured at 2-4 day intervals, showed an initial depression followed by a slow increase, and finally surpassed the control level after about 140 days of carcinogenesis. The results are discussed in relation to findings by other groups, especially with respect to possibly different effects, on RNA synthesis of the two related liver carcinogens DENA and N-nitroso-morpholine.