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  VaporSPOT : parallel synthesis of oligosaccharides on membranes

Tsouka, A., Dallabernardina, P., Mende, M., Sletten, E. T., Leichnitz, S., Bienert, K., et al. (2022). VaporSPOT: parallel synthesis of oligosaccharides on membranes. Journal of the American Chemical Society, 144(43), 19832-19837. doi:10.1021/jacs.2c07285.

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 Creators:
Tsouka, Alexandra1, Author           
Dallabernardina, Pietro1, Author           
Mende, Marco1, Author           
Sletten, Eric T.2, Author           
Leichnitz, Sabrina3, Author           
Bienert, Klaus4, Author           
Le Mai Hoang, Kim, Author
Seeberger, Peter H.2, Author                 
Löffler, Felix F.1, Author           
Affiliations:
1Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2385692              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
3Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              
4Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863284              

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 Abstract: Automated chemical synthesis has revolutionized synthetic access to biopolymers in terms of simplicity and speed. While automated oligosaccharide synthesis has become faster and more versatile, the parallel synthesis of oligosaccharides is not yet possible. Here, a chemical vapor glycosylation strategy (VaporSPOT) is described that enables the simultaneous synthesis of oligosaccharides on a cellulose membrane solid support. Different linkers allow for flexible and straightforward cleavage, purification, and characterization of the target oligosaccharides. This method is the basis for the development of parallel automated glycan synthesis platforms.

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Language(s): eng - English
 Dates: 2022-10-212022
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
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 Identifiers: DOI: 10.1021/jacs.2c07285
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Title: Journal of the American Chemical Society
  Other : JACS
  Abbreviation : J. Am. Chem. Soc.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 144 (43) Sequence Number: - Start / End Page: 19832 - 19837 Identifier: ISSN: 0002-7863