日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
一時保存へ追加
 タグ情報を表示リリース履歴を表示詳細要約
  Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver

Xu, X., Huang, J., Xu, Z. G., Qian, B. Z., Zhu, Z. D., Yan, Q., Cai, T., Zhang, X., Xiao, H. S., Qu, J., Liu, F., Huang, Q. H., Cheng, Z. H., Li, N. G., Du, J. J., Hu, W., Shen, K. T., Lu, G., Fu, G., Zhong, M., Xu, S. H., Gu, W. Y., Huang, W., Zhao, X. T., Hu, G. X., Gu, J. R., Chen, Z., & Han, Z. G. (2001). Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc Natl Acad Sci U S A, 98(26), 15089-94. doi:10.1073/pnas.241522398.

Item is

 

表示: 全項目 非表示: 全項目

基本情報

表示: 非表示:
アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000B-68EB-8 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000B-68EC-7
資料種別: 学術論文

ファイル

表示: ファイル

関連URL

表示:
非表示:
URL:
https://www.ncbi.nlm.nih.gov/pubmed/11752456 (全文テキスト（全般）)
説明:
-
OA-Status:
Not specified

作成者

表示:
非表示:
 作成者:
Xu, X.1, 著者           
Huang, J., 著者
Xu, Z. G., 著者
Qian, B. Z., 著者
Zhu, Z. D., 著者
Yan, Q., 著者
Cai, T., 著者
Zhang, X., 著者
Xiao, H. S., 著者
Qu, J., 著者
Liu, F., 著者
Huang, Q. H., 著者
Cheng, Z. H., 著者
Li, N. G., 著者
Du, J. J., 著者
Hu, W., 著者
Shen, K. T., 著者
Lu, G., 著者
Fu, G., 著者
Zhong, M., 著者
Xu, S. H., 著者Gu, W. Y., 著者Huang, W., 著者Zhao, X. T., 著者Hu, G. X., 著者Gu, J. R., 著者Chen, Z., 著者Han, Z. G., 著者 全て表示
所属:
1Xu – Epigenetic Regulation of Mammalian Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society, ou_3394009              

内容説明

表示:
非表示:
キーワード: Carcinoma, Hepatocellular/*genetics/pathology/virology Cell Transformation, Neoplastic/*genetics DNA, Complementary Expressed Sequence Tags *Gene Expression Profiling Genes, Viral Hepatitis B virus/genetics Humans Liver/*metabolism Liver Neoplasms/*genetics/pathology/virology Molecular Sequence Data Oligonucleotide Array Sequence Analysis Signal Transduction Transcription Factors/genetics *Transcription, Genetic
 要旨: Human hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In this work, we report on a comprehensive characterization of gene expression profiles of hepatitis B virus-positive HCC through the generation of a large set of 5'-read expressed sequence tag (EST) clusters (11,065 in total) from HCC and noncancerous liver samples, which then were applied to a cDNA microarray system containing 12,393 genes/ESTs and to comparison with a public database. The commercial cDNA microarray, which contains 1,176 known genes related to oncogenesis, was used also for profiling gene expression. Integrated data from the above approaches identified 2,253 genes/ESTs as candidates with differential expression. A number of genes related to oncogenesis and hepatic function/differentiation were selected for further semiquantitative reverse transcriptase-PCR analysis in 29 paired HCC/noncancerous liver samples. Many genes involved in cell cycle regulation such as cyclins, cyclin-dependent kinases, and cell cycle negative regulators were deregulated in most patients with HCC. Aberrant expression of the Wnt-beta-catenin pathway and enzymes for DNA replication also could contribute to the pathogenesis of HCC. The alteration of transcription levels was noted in a large number of genes implicated in metabolism, whereas a profile change of others might represent a status of dedifferentiation of the malignant hepatocytes, both considered as potential markers of diagnostic value. Notably, the altered transcriptome profiles in HCC could be correlated to a number of chromosome regions with amplification or loss of heterozygosity, providing one of the underlying causes of the transcription anomaly of HCC.

資料詳細

表示:
非表示:
言語:
 日付: 2001-12-182001
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: その他: 11752456
DOI: 10.1073/pnas.241522398
ISSN: 0027-8424 (Print)0027-8424 (Linking)
 学位: -

関連イベント

表示:

訴訟

表示:

Project information

表示:

出版物 1

表示:
非表示:
出版物名: Proc Natl Acad Sci U S A
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 98 (26) 通巻号: - 開始・終了ページ: 15089 - 94 識別子（ISBN, ISSN, DOIなど）: -