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  Evolution and diversity of TGF-β pathways are linked with novel developmental and behavioural traits

Lo, W.-S., Roca, M., Dardiry, M., Mackie, M., Eberhardt, G., Witte, H., et al. (2022). Evolution and diversity of TGF-β pathways are linked with novel developmental and behavioural traits. Molecular Biology and Evolution, 39(12): msac252. doi:10.1093/molbev/msac252.

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Other : Evolution and diversity of TGF-beta pathways are linked with novel developmental and behavioral trait

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 Creators:
Lo, Wen-Sui1, Author
Roca, Marianne2, Author                 
Dardiry, Mohannad1, Author
Mackie, Marisa1, Author
Eberhardt, Gabi1, Author
Witte, Hanh1, Author
Hong, Ray1, Author
Sommer, Ralf J1, Author
Lightfoot, James W2, Author                 
Ruvinsky, Ilya1, Editor
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society, ou_3361790              

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Free keywords: Caenorhabditis elegans; Pristionchus pacificus; TGF-β signalling; behaviour; behavior ; dauer; developmental systems drift; kin-recognition; phenotypic plasticity; signalling pathway evolution
 Abstract: Transforming growth factor β (TGF-β) signalling is essential for numerous biological functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been pivotal in identifying many components. Utilising a comparative evolutionary approach, we explored TGF-β signalling in nine nematode species and revealed striking variability in TGF-β gene frequency across the lineage. Of the species analysed, gene duplications in the DAF-7 pathway appear common with the greatest disparity observed in Pristionchus pacificus. Specifically, multiple paralogues of daf-3, daf-4 and daf-7 were detected. To investigate this additional diversity, we induced mutations in 22 TGF-β components and generated corresponding double, triple and quadruple mutants revealing both conservation and diversification in function. Although, the DBL-1 pathway regulating body morphology appears highly conserved, the DAF-7 pathway exhibits functional divergence, notably in some aspects of dauer formation. Furthermore, the formation of the phenotypically plastic mouth in P. pacificus is partially influenced through TGF-β with the strongest effect in Ppa-tag-68. This appears important for numerous processes in P. pacificus but has no known function in C. elegans. Finally, we observe behavioural differences in TGF-β mutants including in chemosensation and the establishment of the P. pacificus kin-recognition signal. Thus, TGF-β signalling in nematodes represents a stochastic genetic network capable of generating novel functions through the duplication and deletion of associated genes.

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Language(s): eng - English
 Dates: 2022-12-052022-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/molbev/msac252
PMID: 36469861
ISI: 000895761300001
 Degree: -

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Title: Molecular Biology and Evolution
  Abbreviation : Mol Biol Evol
Source Genre: Journal
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Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 39 (12) Sequence Number: msac252 Start / End Page: - Identifier: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119