Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor 
activation and avoidance behavior

Chang, Simon; Fermani, Federica; Lao, Chu-Lan; Huang, Lianyun; Jakovcevski, Mira; Di Giaimo, Rossella; Gagliardi, Miriam; Menegaz, Danusa; Hennrich, Alexandru Adrian; Ziller, Michael; Eder, Matthias; Klein, Rudiger; Cai, Na; Deussing, Jan M.

doi:10.1126/sciadv.abo1023

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Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior

Chang, S., Fermani, F., Lao, C.-L., Huang, L., Jakovcevski, M., Di Giaimo, R., et al. (2022). Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior. SCIENCE ADVANCES, 8(46). doi:10.1126/sciadv.abo1023.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000C-7BF9-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-7BFA-1

Genre: Journal Article

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Creators:
Chang, Simon¹, Author
Fermani, Federica, Author
Lao, Chu-Lan, Author
Huang, Lianyun, Author
Jakovcevski, Mira², Author
Di Giaimo, Rossella³, Author
Gagliardi, Miriam⁴, Author
Menegaz, Danusa⁵, Author
Hennrich, Alexandru Adrian, Author
Ziller, Michael⁴, Author
Eder, Matthias⁵, Author
Klein, Rudiger, Author
Cai, Na, Author
Deussing, Jan M.¹, Author

Affiliations:
1RG Molecular Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040293
2Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294
3Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society, ou_2173645
4RG Genomics of Complex Diseases, Max Planck Institute of Psychiatry, Max Planck Society, ou_3008285
5Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137

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Abstract: An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin- releasing hormone (CRH) neurons in the lateral part of the interstitial nucleus of the anterior commissure (IPACL), a subdivision of the extended amygdala, which exclusively innervate the substantia nigra ( SN). Specific stimulation of this circuit elicits hyperactivation of the hypothalamic-pituitary-adrenal axis, locomotor activation, and avoidance behavior contingent on CRH receptor type 1 (CRHR1) located at axon terminals in the SN, which originate from external globus pallidus (GPe) neurons. The neuronal activity prompting the observed behavior is shaped by IPACLCRH and GPeCRHR1 neurons coalescing in the SN. These results delineate a previously unidentified tripartite CRH circuit functionally connecting extended amygdala and basal ganglia nuclei to drive locomotor activation and avoidance behavior.

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Dates: Date issued: 2022

Publication Status: Issued

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Identifiers: ISI: 000890338300006
DOI: 10.1126/sciadv.abo1023

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Title: SCIENCE ADVANCES

Source Genre: Journal

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Pages: - Volume / Issue: 8 (46) Sequence Number: - Start / End Page: - Identifier: ISSN: 2375-2548