Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to 
metabolic homeostasis in male and female mice

Brix, Lea; Toksöz, Irmak; Aman, London; Kovarova, Veronika; Springer, Margherita; Bordes, Joeri; van Doeselaar, Lotte; Engelhardt, Clara; Haeusl, Alexander S; Narayan, Sowmya; Sterlemann, Vera; Yang, Huanqing; Deussing, Jan M.; Schmidt, Mathias V.

doi:10.1016/j.molmet.2022.101579

Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice

Brix, L., Toksöz, I., Aman, L., Kovarova, V., Springer, M., Bordes, J., van Doeselaar, L., Engelhardt, C., Haeusl, A. S., Narayan, S., Sterlemann, V., Yang, H., Deussing, J. M., & Schmidt, M. V. (2022). Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice. MOLECULAR METABOLISM, 65:. doi:10.1016/j.molmet.2022.101579.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-000C-CF3E-7 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000C-CF3F-6

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Brix, Lea^{1, 2}, 著者
Toksöz, Irmak¹, 著者
Aman, London¹, 著者
Kovarova, Veronika¹, 著者
Springer, Margherita¹, 著者
Bordes, Joeri^{1, 2}, 著者
van Doeselaar, Lotte^{1, 2}, 著者
Engelhardt, Clara¹, 著者
Haeusl, Alexander S¹, 著者
Narayan, Sowmya^{1, 2}, 著者
Sterlemann, Vera³, 著者
Yang, Huanqing¹, 著者
Deussing, Jan M.⁴, 著者
Schmidt, Mathias V.¹, 著者

所属:
1RG Stress Resilience, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040294
2IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_3318616
3Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137
4RG Molecular Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040293

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要旨: Objective: Steroidogenic factor 1 (SF1) expressing neurons in the ventromedial hypothalamus (VMH) have been directly implicated in whole-body metabolism and in the onset of obesity. The co-chaperone FKBP51 is abundantly expressed in the VMH and was recently linked to type 2 diabetes, insulin resistance, adipogenesis, browning of white adipose tissue (WAT) and bodyweight regulation.
Methods: We investigated the role of FKBP51 in the VMH by conditional deletion and virus-mediated overexpression of FKBP51 in SF1-positive neurons. Baseline and high fat diet (HFD)-induced metabolic- and stress-related phenotypes in male and female mice were obtained.
Results: In contrast to previously reported robust phenotypes of FKBP51 manipulation in the entire mediobasal hypothalamus (MBH), selective deletion or overexpression of FKBP51 in the VMH resulted in only a moderate alteration of HFD-induced bodyweight gain and body composition, independent of sex.
Conclusions: Overall, this study shows that animals lacking and overexpressing Fkbp5 in Sf1-expressing cells within the VMH display only a mild metabolic phenotype compared to an MBH-wide manipulation of this gene, suggesting that FKBP51 in SF1 neurons within this hypothalamic nucleus plays a subsidiary role in controlling whole-body metabolism. (c) 2022 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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日付: オンライン出版: 2022

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識別子（DOI, ISBNなど）: ISI: 000906466700004
DOI: 10.1016/j.molmet.2022.101579

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出版物名: MOLECULAR METABOLISM

種別: 学術雑誌

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ページ: - 巻号: 65 通巻号: 101579 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2212-8778

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